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Digital tools to improve parenting behaviour in low-income settings: a mixed-methods feasibility study
(2023)Archives of Disease in ChildhoodIntroduction Digital parenting interventions could be potentially cost-effective means for providing early child development services in low-income settings. This 5-month mixed-methods pilot study evaluated the feasibility of using Afinidata, a comprehensive Facebook Messenger-based digital parenting intervention in a remote rural setting in Latin America and explored necessary adaptations to local context. Methods The study was conducted ...Journal Article -
Near-bed stratification controls bottom hypoxia in ice-covered alpine lakes
(2023)Limnology and OceanographyIn ice-covered lakes, near-bottom oxygen concentration decreases for most of the wintertime, sometimes down to the point that bottom waters become hypoxic. Studies insofar have reached divergent conclusions on whether climate change limits or reinforces the extent and duration of hypoxia under ice, raising the need for a comprehensive understanding of the drivers of the dissolved oxygen (DO) dynamics under lake ice. Using high-temporal ...Journal Article -
Exploring the epidemiology of mcr genes, genetic context and plasmids in Enterobacteriaceae originating from pigs and humans on farms in Thailand
(2023)Journal of Antimicrobial ChemotherapyObjectives: In veterinary medicine, colistin has been widely used as therapeutic and prophylactic agent, and for growth promotion. However, colistin has been re-introduced into treatment of human MDR bacterial infections. We assessed the characteristics and spread of plasmid-borne colistin resistance among healthy pigs, workers with animal-contact and their household members in Thailand. Methods: WGS and MIC data of 146 mcr-positive ...Journal Article -
Timing, Thrusting Mode, and Negative Inversion Along the Circeo Thrust, Apennines, Italy: How the Accretion-To-Extension Transition Operated During Slab Rollback
(2023)TectonicsThe evolution of the Apennine wedge has seen the time-space migration of the forebulge, foredeep, thrust wedge, and back-arc extension phases in the wake of the Eastward rollback of the subducting Adria slab. In this framework, thrusting and post-orogenic extensional faulting have occurred in two parallel forelandward-migrating ribbons, with extensional deformation overprinting or partly exploiting anisotropies of the inherited thrust ...Journal Article -
VISITOR: Visual Interactive State Sequence Exploration for Reinforcement Learning
(2023)Computer Graphics ForumUnderstanding the behavior of deep reinforcement learning agents is a crucial requirement throughout their development. Existing work has addressed the identification of observable behavioral patterns in state sequences or analysis of isolated internal representations; however, the overall decision-making of deep-learning RL agents remains opaque. To tackle this, we present VISITOR, a visual analytics system enabling the analysis of entire ...Journal Article -
Hypocenter-Based 3D Imaging of Active Faults: Method and Applications in the Southwestern Swiss Alps
(2023)Journal of Geophysical Research: Solid EarthDespite the fact that earthquake occurrence can be strongly influenced by the architecture of pre-existing faults, it remains challenging to obtain information about the detailed subsurface geometries of active fault systems. Current geophysical methods for studying such systems often fail to resolve geometrical complexities at sufficiently high spatial resolutions. In this work, we present a novel method for imaging the detailed 3D ...Journal Article -
Developing and Extending Status Prediction Models for Railway Tracks Based on On-Board Monitoring Data
(2023)Transportation Research RecordAssigning inspection trains to monitor track quality is a standard procedure for maintaining railway system safety. The main challenges lie in lacking time and resources to perform the inspections because of the increasing traffic nowadays. To overcome these challenges, many consider adopting the on-board monitoring (OBM) technique for performing the inspections. This technique assigns commercial trains, instead of traditional track ...Journal Article -
Multiple Large-Scale Dynamical Pathways for Pan–Atlantic Compound Cold and Windy Extremes
(2023)Geophysical Research LettersWinter cold spells over North America have been correlated with European wind extremes, but the physical mechanisms behind such “pan-Atlantic” compound extremes have not been clarified yet. In this study, we propose that pan–Atlantic cold and windy extremes occur following two possible dynamical pathways. The first one involves the propagation of a Rossby wave train from the Pacific Ocean, associated with windstorms over north-western ...Journal Article -
A Water- and Base-Stable Iminopyridine-Based Cage That Can Bind Larger Organic Anions
(2023)European Journal of Inorganic ChemistryCatalysis inside molecular cages and capsules has attracted an increasing amount of attention over the last decade. While many examples of the catalysis of reactions with cationic intermediates and transition states are known, those with anionic counterparts are scarce. One limiting factor is access to suitably sized cationic iminopyridine-based cages that are stable towards water and anionic/nucleophilic guest molecules. This study aimed ...Journal Article -
BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility
(2023)Nucleic Acids ResearchThe transcription factor BTB and CNC homology 1(BACH1) has been linked to coronary artery disease risk by human genome-wide association studies, but little is known about the role of BACH1 in vascular smooth muscle cell (VSMC) phenotype switching and neointima formation following vascular injury. Therefore, this study aims to explore the role of BACH1 in vascular remodeling and its underlying mechanisms. BACH1 was highly expressed in human ...Journal Article