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Developmental Selection and the Perception of Mutation Bias
(2023)Molecular Biology and EvolutionThe notion that mutations are random relative to their fitness effects is central to the Neo-Darwinian view of evolution. However, a recent interpretation of the patterns of mutation accumulation in the genome of Arabidopsis thaliana has challenged this notion, arguing for the presence of a targeted DNA repair mechanism that causes a nonrandom association of mutation rates and fitness effects. Specifically, this mechanism was suggested ...Journal Article -
Facing Change With Stability: The Dynamics of Occupational Career Trajectories
(2023)Journal of Career DevelopmentIn today's dynamic work environments, individuals must manage their careers. Although research suggests that many individuals change jobs and organizations more frequently, they often pursue their careers within one occupation still. The current study addresses how such seemingly stable careers unfold in the face of societal, economic, and technological changes and explores the proactive and reactive strategies individuals use to sustain ...Journal Article -
A Depth-Averaged Material Point Method for Shallow Landslides: Applications to Snow Slab Avalanche Release
(2023)Journal of Geophysical Research: Earth SurfaceShallow landslides pose a significant threat to people and infrastructure. Despite significant progress in the understanding of such phenomena, the evaluation of the size of the landslide release zone, a crucial input for risk assessment, still remains a challenge. While often modeled based on limit equilibrium analysis, finite or discrete elements, continuum particle-based approaches like the Material Point Method (MPM) have more recently ...Journal Article -
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
(2023)The British Journal of RadiologyObjectives The purpose of this study is to report the oncological outcome, observed toxicities and normal tissue complication probability (NTCP) calculation for pencil beam scanning (PBS) PT delivered to salivary gland tumour (SGT) patients. Methods We retrospectively reviewed 26 SGT patients treated with PBSPT (median dose, 67.5 Gy(RBE)) between 2005 and 2020 at our institute. Toxicities were recorded according to CTCAEv.4.1. Overall ...Journal Article -
Magnetic blood purification-based soluble fms-like tyrosine kinase-1 removal in comparison with dextran sulfate apheresis and therapeutic plasma exchange
(2023)Artificial OrgansBackground Preeclampsia remains one of the most serious complications of pregnancy. Effective therapies are yet to be developed. Recent research has identified an imbalance of angiogenic and antiangiogenic factors as a root cause of preeclampsia. In particular, soluble fms-like tyrosine kinase-1 (sFlt-1) has been shown to bind the angiogenic factors vascular endothelial growth factor (VEGF) and placental growth factor (PlGF), reducing ...Journal Article -
Environmentally independent selection for hybrids between divergent freshwater stickleback lineages in semi-natural ponds
(2023)Journal of Evolutionary BiologyHybridization following secondary contact of genetically divergent populations can influence the range expansion of invasive species, though specific outcomes depend on the environmental dependence of hybrid fitness. Here, using two genetically and ecologically divergent threespine stickleback lineages that differ in their history of freshwater colonization, we estimate fitness variation of parental lineages and hybrids in semi-natural ...Journal Article -
Fault Zone Spatial Stress Variations in a Granitic Rock Mass: Revealed by Breakouts Within an Array of Boreholes
(2023)Journal of Geophysical Research: Solid EarthThe in situ stress state within fault zones is technically challenging to characterize. At the Bedretto Underground Laboratory in the Swiss Alps, the breakouts observed in an array of eight inclined boreholes penetrating a fault zone offer a unique opportunity to characterize the fault-associated spatial stress variations. Synthesizing multiple geophysical logs, natural geologic structures intersecting these boreholes are identified, ...Journal Article -
Paper-Based Laser-Pyrolyzed Electrofluidics: An Electrochemical Platform for Capillary-Driven Diagnostic Bioassays
(2023)Advanced MaterialsMicrofluidic paper-based analytical devices (µPADs) are indispensable tools for disease diagnostics. The integration of electronic components into µPADs enables new device functionalities and facilitates the development of complex quantitative assays. Unfortunately, current electrode fabrication methods often hinder capillary flow, considerably restricting µPAD design architectures. Here, laser-induced graphenization is presented as an ...Journal Article -
Simulating Hail and Lightning Over the Alpine Adriatic Region—A Model Intercomparison Study
(2023)Journal of Geophysical Research: AtmospheresHail is a significant convective weather hazard, often causing considerable crop and property damage across the world. Although extremely damaging, hail still remains a challenging phenomenon to model and forecast, given the limited computational resolution and the gaps in understanding the processes involved in hail formation. Here, eight hailstorms occurring over the Alpine-Adriatic region are analyzed using simulations with the Weather ...Journal Article -
Abundant presolar grains and primordial organics preserved in carbon-rich exogenous clasts in asteroid Ryugu
(2023)Science AdvancesPreliminary analyses of asteroid Ryugu samples show kinship to aqueously altered CI (Ivuna-type) chondrites, suggesting similar origins. We report identification of C-rich, particularly primitive clasts in Ryugu samples that contain preserved presolar silicate grains and exceptional abundances of presolar SiC and isotopically anomalous organic matter. The high presolar silicate abundance (104 ppm) indicates that the clast escaped extensive ...Journal Article