Open access
Datum
2019-07Typ
- Review Article
Abstract
Bacterial natural products display astounding structural diversity, which, in turn, endows them with a remarkable range of biological activities that are of significant value to modern society. Such structural features are generated by biosynthetic enzymes that construct core scaffolds or perform peripheral modifications, and can thus define natural product families, introduce pharmacophores and permit metabolic diversification. Modern genomics approaches have greatly enhanced our ability to access and characterize natural product pathways via sequence-similarity-based bioinformatics discovery strategies. However, many biosynthetic enzymes catalyse exceptional, unprecedented transformations that continue to defy functional prediction and remain hidden from us in bacterial (meta)genomic sequence data. In this Review, we highlight exciting examples of unusual enzymology that have been uncovered recently in the context of natural product biosynthesis. These suggest that much of the natural product diversity, including entire substance classes, awaits discovery. New approaches to lift the veil on the cryptic chemistries of the natural product universe are also discussed. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000353919Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Nature Reviews ChemistryBand
Seiten / Artikelnummer
Verlag
NatureOrganisationseinheit
03980 - Piel, Jörn / Piel, Jörn
Förderung
146992 - Biosynthetic studies on proteusins, a peptide family with unprecedented modifications (SNF)
167051 - Ecosystem- and genome-guided antibiotic discovery (SNF)
Anmerkungen
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.