Stem Cell-Based and Tissue Engineering Approaches for Skeletal Muscle Repair
Open access
Datum
2020Typ
- Book Chapter
ETH Bibliographie
yes
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Abstract
Skeletal muscle tissue exhibits significant regeneration capacity upon injury or disease. This intrinsic regeneration potential is orchestrated by stem cells termed satellite cells, which undergo activation and differentiation in response to muscle insult, giving rise to fusion-competent myogenic progenitors responsible for tissue rejuvenation. Skeletal muscle diseases such as Duchenne muscular dystro-phy are characterized by progressive loss of muscle mass which precipitates reduced motility, paralysis, and in some occurrences untimely death. A manifold of muscle pathologies involve a failure to efficiently regenerate the muscle tissue, rendering stem cell-based approaches an attractive therapeutic strategy. Here we will present past and contemporary methods to treat skeletal muscle degeneration by stem cell therapy, covering prominent challenges facing this technology and potential means to overcome current hurdles. A primary focus of this chapter is directed toward illustrating innovative ways to utilize stem cells alone or in conjunction with biomaterials and tissue engineering techniques to remedy Duchenne muscular dystrophy or volumetric muscle loss. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000430184Publikationsstatus
publishedExterne Links
Printexemplar via ETH-Bibliothek suchen
Buchtitel
Organ Tissue EngineeringZeitschrift / Serie
Reference Series in Biomedical EngineeringSeiten / Artikelnummer
Verlag
SpringerOrganisationseinheit
09626 - Bar-Nur, Ori / Bar-Nur, Ori
ETH Bibliographie
yes
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