Abstract
Structural virology reveals the architecture underlying infection. While notably electron microscopy images have provided an atomic view on viruses which profoundly changed our understanding of these assemblies incapable of independent life, spectroscopic techniques like NMR enter the field with their strengths in detailed conformational analysis and investigation of dynamic behavior. Typically, the large assemblies represented by viral particles fall in the regime of biological high-resolution solid-state NMR, able to follow with high sensitivity the path of the viral proteins through their interactions and maturation steps during the viral life cycle. We here trace the way from first solid-state NMR investigations to the state-of-the-art approaches currently developing, including applications focused on HIV, HBV, HCV and influenza, and an outlook to the possibilities opening in the coming years. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000445431Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
VirusesBand
Seiten / Artikelnummer
Verlag
MDPIThema
structure; solid-state NMR; viral proteins; capsids; membrane proteinsOrganisationseinheit
03496 - Meier, Beat H. (emeritus) / Meier, Beat H. (emeritus)