Development and evaluation of modulated arc technique for total body irradiation radiotherapy
Open access
Autor(in)
Datum
2020-10Typ
- Master Thesis
ETH Bibliographie
yes
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Abstract
Total Body Irradiation (TBI) is a type of Radiation Therapy (RT) technique, used for irradiation of the whole patient body. The standard way of TBI is based on static photon beams with more than 3 m long distance between the radiation source and the patient. But it is often not possible in smaller size radiation therapy rooms in many RT centers.
Modulated Arc (mARC) technique for TBI, is one of the techniques to perform TBI with a standard linear accelerator in smaller size RT rooms and does not require special equipment. Commercial treatment planning systems (TPS) for RT, at least Varian Eclipse® used in University Hospital Zurich (USZ), do not offer a dedicated planning option for ARC mode TBI.
In this work, a new calculation method for mARC parameters has been developed. It is based on an optimization algorithm from Python 3 library SciPy, calculating the ratio of field weights in mARC, which leads to optimized dose distribution in the patient. Optimization can be customized according to the size of the patient and required dose homogeneity. The method was tested on virtual water phantoms mARC planning in TPS and with confirmative measurement on the linear accelerator with long solid water slab phantom. An example of the treatment plan in mARC mode was prepared and evaluated using CTs of one real TBI patient. The proposed mARC method performed well in the preliminary evaluations, and we can recommend it to be considered for clinical use in TBI therapy in USZ. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000489836Publikationsstatus
publishedBeteiligte
Referent: Krayenbühl, Jérôme
Verlag
ETH ZurichThema
total body irradiation; tbi; modulated arc; radiotherapyOrganisationseinheit
02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering
ETH Bibliographie
yes
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