Open access
Datum
2022-08Typ
- Review Article
Abstract
Metastasis is a leading cause of cancer-related death and consists of a sequence of events including tumor expansion, intravasation of cancer cells into the circulation, survival in the bloodstream, extravasation at distant sites, and subsequent organ colonization. Particularly, intravasation is a process whereby cancer cells transverse the endothelium and leave the primary tumor site, pioneering the metastatic cascade. The identification of those mechanisms that trigger the entry of cancer cells into the bloodstream may reveal fundamentally novel ways to block metastasis at its start. Multiple factors have been implicated in cancer progression, yet, signals that unequivocally provoke the detachment of cancer cells from the primary tumor are still under investigation. Here, we discuss the role of intrinsic properties of cancer cells, tumor microenvironment, and mechanical cues in the intravasation process, outlining studies that suggest the involvement of various factors and highlighting current understanding and open questions in the field. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000494757Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
The FEBS JournalBand
Seiten / Artikelnummer
Verlag
WileyThema
cancer; circulating tumor cells; intravasation; metastasisOrganisationseinheit
09736 - Aceto, Nicola / Aceto, Nicola
Förderung
190077 - SNF-Förderungsprofessur PP00P3_190077 (SNF)
847012 - Understanding why the 'metastasisers' colonise and other circulating cancer cells do not (EC)