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Date
2024-07Type
- Review Article
ETH Bibliography
yes
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Abstract
Inteins are proteins found in nature that execute protein splicing. Among them, split inteins stand out for their versatility and adaptability, presenting creative solutions for addressing intricate challenges in various biological applications. Their exquisite attributes, including compactness, reliability, orthogonality, low toxicity, and irreversibility, make them of interest to various fields including synthetic biology, biotechnology and biomedicine. In this review, we delve into the inherent challenges of using inteins, present approaches for overcoming these challenges, and detail their reliable use for specific cellular tasks. We will discuss the use of conditional inteins in areas like cancer therapy, drug screening, patterning, infection treatment, diagnostics and biocontainment. Additionally, we will underscore the potential of inteins in executing basic logical operations with practical implications. We conclude by showcasing their potential in crafting complex genetic circuits for performing computations and feedback control that achieves robust perfect adaptation. Show more
Publication status
publishedExternal links
Journal / series
Biotechnology AdvancesVolume
Pages / Article No.
Publisher
ElsevierSubject
Inteins; Biotechnology; Synthetic biology; Genetic circuits; Feedback controlFunding
216505 - Theory and Design of Advanced Genetically Engineered Control Systems (SNF)
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ETH Bibliography
yes
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