Taking the lymphatic route: dendritic cell migration to draining lymph nodes
Open access
Date
2014-03Type
- Journal Article
Abstract
In contrast to leukocyte migration through blood vessels, trafficking via lymphatic vessels (LVs) is much less well characterized. An important cell type migrating via this route is antigen-presenting dendritic cells (DCs), which are key for the induction of protective immunity as well as for the maintenance of immunological tolerance. In this review, we will summarize and discuss current knowledge of the cellular and molecular events that control DC migration from the skin towards, into, and within LVs, followed by DC arrival and migration in draining lymph nodes. Finally, we will discuss potential strategies to therapeutically target this migratory step to modulate immune responses. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000079467Publication status
publishedExternal links
Journal / series
Seminars in ImmunopathologyVolume
Pages / Article No.
Publisher
SpringerSubject
Dendritic cells; Migration; Lymphatic vessels; Draining lymph node; CCL21Organisational unit
03816 - Halin Winter, Cornelia / Halin Winter, Cornelia
Funding
138330 - Elucidating the impact of inflammation on lymphatic vessel function and on the induction of adaptive immunity (SNF)
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.More
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