Changes in Corticomotor Excitability and Intracortical Inhibition of the Primary Motor Cortex Forearm Area Induced by Anodal tDCS
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Datum
2014-07-07Typ
- Journal Article
ETH Bibliographie
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Abstract
Objective
Previous studies have investigated how tDCS over the primary motor cortex modulates excitability in the intrinsic hand muscles. Here, we tested if tDCS changes corticomotor excitability and/or cortical inhibition when measured in the extensor carpi radialis (ECR) and if these aftereffects can be successfully assessed during controlled muscle contraction.
Methods
We implemented a double blind cross-over design in which participants (n = 16) completed two sessions where the aftereffects of 20 min of 1 mA (0.04 mA/cm2) anodal vs sham tDCS were tested in a resting muscle, and two more sessions where the aftereffects of anodal vs sham tDCS were tested in an active muscle.
Results
Anodal tDCS increased corticomotor excitability in ECR when aftereffects were measured with a low-level controlled muscle contraction. Furthermore, anodal tDCS decreased short interval intracortical inhibition but only when measured at rest and after non-responders (n = 2) were removed. We found no changes in the cortical silent period.
Conclusion
These findings suggest that targeting more proximal muscles in the upper limb with anodal tDCS is achievable and corticomotor excitability can be assessed in the presence of a low-level controlled contraction of the target muscle. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000087142Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
PLoS ONEBand
Seiten / Artikelnummer
Verlag
PLOSOrganisationseinheit
03963 - Wenderoth, Nicole / Wenderoth, Nicole
ETH Bibliographie
yes
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