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Feasibility study to achieve hypofractionated proton therapy within a single breath- hold for lung cancer
(2021)Conference Poster -
New Gantry Beam Optics Solution for Minimising Treatment Time in Cyclotron-based Proton Therapy Facilities
(2021)Treatment delivery time in proton therapy depends on beam-on time and the time required to change energy layers and/or lateral position. For cyclotron-based facilities, low energy beams (100-70 MeV) are inefficiently transported through beamlines due to their large emittance after the degrader (~400 pi*mm*mrad 2-sigma emittance), whereas the beamline and Gantry can only transport small emittances (e.g. 30 pi*mm*mrad for PSI Gantry 2) ...Conference Poster -
A novel intensity compensation method to achieve energy independent beam intensity at the patient location for cyclotron based proton therapy facilities
(2022)In cyclotron-based proton therapy facilities, an energy selection system is typically used to lower the beam energy from the fixed value provided by the accelerator (250/230 MeV) to the one needed for the treatment (230-70 MeV). Such a system has the drawback of increase beam emittance and introducing an energy-dependent beam current at the patient location, resulting in energy-dependent beam intensity ratios of about 10^3 between high ...Conference Poster -
A novel energy selection system to achieve FLASH dose-rates even for low-energy beams in cyclotron-based proton therapy facilities
(2022)In proton therapy, the potential of ultra-high (FLASH) dose-rate for cancer treatment is being explored due to its potential for enhancing biological effect, faster hypo-fractionated treatments and for efficient motion mitigation. However, energy degradation for FLASH irradiations using cyclotrons is far from optimal; if performed upstream (as common clinically, using a degrader plus an energy/momentum selection system, or ESS), very large ...Conference Poster -
A novel method of emittance matching to increase beam transmission for cyclotron-based proton therapy facilities: simulation study
(2022)In proton therapy, high dose rates can reduce treatment delivery times, allowing for efficient mitigation of tumor motion and increased patient throughput. With cyclotrons however, high dose rates are difficult to achieve for low-energies as, typically, the emittance after the degrader is matched in both transversal planes using circular collimators, which does not provide an optimal matching to the acceptance of the following beamline. ...Conference Poster -
Use of momentum cooling to achieve flash dose-rates even for low-energy beams in cyclotron-based proton therapy facilities
(2022)Background and Aims: In proton therapy, the potential high dose-rates (FLASH) for cancer treatment is currently being explored. If performed with cyclotrons however, energy degradation is required. If performed upstream (using a degrader plus and energy/momentum selection system (ESS)), large beam losses result, whilst if performed downstream, just before the patient, the beam width is substantially compromised. In both cases, the net ...Conference Poster -