DNA-Encoded Chemical Libraries
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Author / Creator
Date
2006-11
Publication Type
Review Article
ETH Bibliography
yes
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Abstract
Conventional libraries of chemical compounds, which are individually screened for binding to pharmaceutical targets, are typically limited by screening costs and logistics to an upper size of few hundred thousand compounds. The use of DNA‐encoded chemical libraries promises to revolutionize the way chemical libraries are screened, allowing the synthesis and selection of libraries of unprecedented size. This article reviews the most recent strategies for the construction and selection of DNA‐encoded chemical libraries.
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Publication status
published
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Journal / series
Volume
25 (11)
Pages / Article No.
1081 - 1087
Publisher
Wiley-VCH
Event
Edition / version
Methods
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Date collected
Date created
Subject
Affinity maturation; Combinatorial chemistry; DNA-templated chemistry; Encoded self-assembling chemical libraries; Lead identification