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Staub, Fridolin; Vargas Meleza, Liliana; Gischig, Valentin; et al. (2025)
The BEACH experiment aims to investigate hydrothermal injections using all boreholes in the Geothermal Testbed of the BedrettoLab. The experimental phase began with cold fluid injection, followed by warm fluid injection. Injection pressures remained below jacking pressure. A krypton tracer test was carried out during the injection, to investigate the water flow paths within the test volume. This publication provides down-sampled data and jupyter notebook to visualize all datasets collected in the BEACH project, which are fully described in the BEACH-Data-Report-v1 in this publication.
This is a copy of the BEACH git repository, which contains data and scripts necessary to run the jupyter notebooks for each data type. Unzip the compressed files and follow the instructions in the README.md file.
Contents
.gitignore
3D_model.zip
DSS.zip
DTS.zip
ETHZ_BEACH_Experiment_Data_Report_v1.pdf
FBG.zip
Hydraulic.zip
Logbook.zip
README.md
Seismics.zip
The effects of omega-3 fatty acids on Wnt activity in iPSC-derived neural stem cells from adult ADHD patients
Item type: Journal Article
Yde Ohki, Cristine M.; Walter, Natalie M.; Dury, Louisa C.; et al. (2026)
The canonical Wnt signaling pathway plays a key role in neurodevelopment and in maintaining cellular homeostasis of the central nervous system in adulthood. It regulates essential processes, such as cell proliferation, differentiation, and synaptogenesis. In vivo and genetic evidence suggests an association between attention-deficit/hyperactivity disorder (ADHD) and abnormalities in the Wnt pathway. Prior research from our group indicated heightened basal Wnt activity in neural stem cells (NSCs) derived from induced pluripotent stem cells (iPSCs) of pediatric ADHD patients and showed that methylphenidate (MPH) and omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can modulate this pathway. While MPH is a first-line treatment for ADHD, ω-3 PUFAs are under investigation as a potential non-pharmacological supplement. Using the same functionality-based reporter technology, we assessed Wnt activity in iPSC-derived NSCs from 5 adult ADHD patients and 5 healthy controls. We examined whether ω-3 fatty acids (EPA and DHA), alone or combined, and DHA with MPH can modulate Wnt activity in these NSCs. Basal Wnt responsiveness did not differ between adult ADHD and control lines, although genetic risk for ADHD was associated with increased Wnt activity. EPA showed no statistically significant effects, while DHA strongly increased Wnt activity in both groups. DHA combined with EPA increased Wnt activity in ADHD lines, whereas DHA with MPH caused group-specific responses: enhancing Wnt signaling in ADHD but reducing it in controls. Compared to NSCs derived from children, adult-derived NSCs behave differently and show distinct responses to EPA and DHA, suggesting a potential route toward refined therapeutic strategies for adults.
Potassium depolarized rat uterus in response to oxytocin and its structural analogues: kinetic analysis
Item type: Journal Article
Pliska, Vladimir; Crankshaw, Denis J. (2026)
The subject of this communication is the kinetic analysis of dynamic processes in the myometrium of rats in a depolarized state, with a focus on their biomechanics and possible implications in obstetrics. Depolarization was achieved by increasing the concentration of K+ in the organ bath. It is attended by a fast transient increase in muscle tension and the slower establishment of a new resting state in which the phasic component of contractile activity is suppressed. The myometrium remains stimulable by oxytocin and its structural analogues. Time-tonic response profiles indicate participation of several superimposed, time-dependent exponential components whose rate constants reflect transport and distribution routes regulating the intracellular calcium concentration. The initial rapid rise in tension is followed by a slower change to a steady-state level. Its interruption by oil immersion is followed by an exponential tension decline which allows the determination of the affinity constants of OXT peptides in the depolarized state. The average potency ratio polarized-to-depolarized myometrium assessed for 11 OXT peptides is 9.14. There was no evidence of ligand bias between the two states. Kinetic analysis of the response profiles shows a satisfactory consistency with the reported changes in calcium sensitization and transport processes following OXT stimulation.
Swiss Panel Global Cooperation 2025
Item type: Report
Patel, Shruti; Markhof, Yannick; Brugger, Fritz; et al. (2025)
Vanishing and vanished glaciers
Item type: Journal Article
Andreassen, Liss Marie; Aðalgeirsdóttir, Guðfinna; Berthier, Etienne; et al. (2026)
We summarize and reflect on the nearly 30 studies that form this Collection on Vanishing Glaciers as a contribution to the 2025 International Year of Glaciers' Preservation. Some of the studies in this Collection are extensions of the stories told in the Global Glacier Casualty List, a collaboration between social and physical scientists. They document glaciers in various states of demise in regions across six continents, including Svalbard, Iceland, Norway, Germany, France, Italy, Spain, Austria, Switzerland, New Zealand, Indonesia, USA, Canada, Peru, Bolivia and Chile. Vanishing glaciers affect archaeology, biodiversity, water resources, tourism, culture and glaciology itself, as we grapple with more precise definitions of dwindling ice masses and the loss of long-term monitoring sites. Landscapes are being transformed by rapid deglaciation, serving as a call to action and introducing numerous challenges for those engaged in measuring, monitoring and documenting glacier change.