1. Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers 

   Fischer J.R.; Jackson H.W.; de Souza N.; et al. (2023)

   Cell Reports Medicine

   Although breast cancer mortality is largely caused by metastasis, clinical decisions are based on analysis of the primary tumor and on lymph node involvement but not on the phenotype of disseminated cells. Here, we use multiplex imaging mass cytometry to compare single-cell phenotypes of primary breast tumors and matched lymph node metastases in 205 patients. We observe extensive phenotypic variability between primary and metastatic sites ...

   Journal Article

2. An integrated single cell and spatial transcriptomic map of human white adipose tissue 

   Massier L.; Jalkanen J.; Elmastas M.; et al. (2023)

   Nature Communications

   To date, single-cell studies of human white adipose tissue (WAT) have been based on small cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a comprehensive meta-analysis of publicly available and newly generated single-cell, single-nucleus, and spatial transcriptomic results from human subcutaneous, omental, and perivascular WAT. Our high-resolution map is built on data from ten studies and allowed us to ...

   Journal Article

3. Bilayer Dense-Porous Li<inf>7</inf>La<inf>3</inf>Zr<inf>2</inf>O<inf>12</inf> Membranes for High-Performance Li-Garnet Solid-State Batteries 

   Zhang H.; Okur F.; Cancellieri C.; et al. (2023)

   Advanced Science

   Li dendrites form in Li7La3Zr2O12 (LLZO) solid electrolytes due to intrinsic volume changes of Li and the appearance of voids at the Li metal/LLZO interface. Bilayer dense-porous LLZO membranes make for a compelling solution of this pertinent challenge in the field of Li-garnet solid-state batteries (SSB). Lithium is thus stored in the pores of the LLZO, thereby avoiding i) dynamic changes of the anode volume and ii) the formation of voids ...

   Journal Article

4. Application of the Pseudo-Global Warming Approach in a Kilometer-Resolution Climate Simulation of the Tropics 

   Heim C.; Leutwyler D.; Schär C. (2023)

   Journal of Geophysical Research: Atmospheres

   Clouds over tropical oceans are an important factor in the Earth's response to increased greenhouse gas concentrations, but their representation in climate models is challenging due to the small-scale nature of the involved convective processes. We perform two 4-year-long simulations at kilometer-resolution (3.3 km horizontal grid spacing) with the limited-area model COSMO over the tropical Atlantic on a 9,000 × 7,000 km2 domain: A control ...

   Journal Article

5. High-Frequency 3D LiDAR Measurements of a Debris Flow: A Novel Method to Investigate the Dynamics of Full-Scale Events in the Field 

   Aaron J.; Spielmann R.; McArdell B.W.; et al. (2023)

   Geophysical Research Letters

   Surging debris flows are among the most destructive natural hazards, and elucidating the interaction between coarse-grained fronts and the trailing liquefied slurry is key to understanding these flows. Here, we describe the application of high-resolution and high-frequency 3D LiDAR data to explore the dynamics of a debris flow at Illgraben, Switzerland. The LiDAR measurements facilitate automated detection of features on the flow surface, ...

   Journal Article

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