1. The climate and vegetation of Europe, northern Africa, and the Middle East during the Last Glacial Maximum (21 000 yr BP) based on pollen data 

   Davis, Basil A. S.; Fasel, Marc; Kaplan, Jed O.; et al. (2024)

   Climate of the Past

   Pollen data represent one of the most widely available and spatially resolved sources of information about the past land cover and climate of the Last Glacial Maximum (LGM; 21 000 yr BP). Previous pollen data compilations for Europe, the Mediterranean, and the Middle East, however, have been limited by small numbers of sites and poor dating control. Here we present a new compilation of pollen data from the region that improves on both the ...

   Journal Article

2. Enriching productive mutational paths accelerates enzyme evolution 

   Patsch, David; Schwander, Thomas; Voss, Moritz; et al. (2024)

   Nature Chemical Biology

   Darwinian evolution has given rise to all the enzymes that enable life on Earth. Mimicking natural selection, scientists have learned to tailor these biocatalysts through recursive cycles of mutation, selection and amplification, often relying on screening large protein libraries to productively modulate the complex interplay between protein structure, dynamics and function. Here we show that by removing destabilizing mutations at the ...

   Journal Article

3. Modelling subglacial fluvial sediment transport with a graph-based model, Graphical Subglacial Sediment Transport (GraphSSeT) 

   Aitken, Alan Robert Alexander; Delaney, Ian; Pirot, Guillaume; et al. (2024)

   The Cryosphere

   A quantitative understanding of how sediment discharge from subglacial fluvial systems varies in response to glaciohydrological conditions is essential for understanding marine systems around Greenland and Antarctica and for interpreting sedimentary records of cryosphere evolution. Here we develop a graph-based approach, Graphical Subglacial Sediment Transport (GraphSSeT), to model subglacial fluvial sedimentary transport using subglacial ...

   Journal Article

4. Developing an exercise intervention to minimise hip bone mineral density loss following traumatic lower limb amputation: a Delphi study 

   Behan, Fearghal P.; Bull, Anthony M. J.; Beck, Belinda R.; et al. (2024)

   British Journal of Sports Medicine

   Objective To elicit expert opinion and gain consensus on specific exercise intervention parameters to minimise hip bone mineral density (BMD) loss following traumatic lower limb amputation. Methods In three Delphi rounds, statements were presented to a panel of 13 experts from six countries. Experts were identified through publications or clinical expertise. Round 1 involved participants rating their agreement with 22 exercise prescription ...

   Journal Article

5. Hypertension and cerebral blood flow in the development of Alzheimer's disease 

   Bachmann, Dario; Saake, Antje; Studer, Sandro; et al. (2024)

   Alzheimer's & Dementia: The Journal of the Alzheimer's Association

   INTRODUCTION: We investigated the interactive associations between amyloid and hypertension on the entorhinal cortex (EC) tau and atrophy and the role of cerebral blood flow (CBF) as a shared mechanism by which amyloid and hypertension contribute to EC tau and regional white matter hyperintensities (WMHs). METHODS: We analyzed data from older adults without dementia participating in the Add-Tau study (NCT02958670, n = 138) or Alzheimer's ...

   Journal Article

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