1. Midazolam at Low Nanomolar Concentrations Affects Long-term Potentiation and Synaptic Transmission Predominantly via the alpha(1)-gamma-Aminobutyric Acid Type A Receptor Subunit in Mice 

   Puig-Bosch, Xenia; Bieletzki, Stefan; Zeilhofer, Hanns Ulrich; et al. (2022)

   Anesthesiology

   Background: Midazolam amplifies synaptic inhibition via different gamma-aminobutyric acid type A (GABA(A)) receptor subtypes defined by the presence of or alpha(1)-, alpha(2)-, alpha(3)-, or alpha(5)-subunits in the channel complex. Midazolam blocks long-term potentiation and produces postoperative amnesia. The aims of this study were to identify the GABA(A) receptor subtypes targeted by midazolam responsible for affecting CA1 long-term ...

   Journal Article

2. A high dimensional map of phosphorylation-dependent signaling in budding yeast 

   Villen J.; Leutert M.; Barente A.; et al. (2022)

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology

   Development of mass spectrometry-based phosphoproteomics has substantially expanded our understanding of cellular processes regulated by protein phosphorylation. However, most phosphoproteomic studies are low dimensional (<5 conditions) due to analytical limitations. Phosphoproteomic profiling at much higher dimensionality is required to obtain systematic insight into the architecture and function of phosphorylation-dependent signaling ...

   Journal Article

3. Cascaded Parsing of Human-Object Interaction Recognition 

   Zhou T.; Qi S.; Wang W.; et al. (2022)

   IEEE Transactions on Pattern Analysis and Machine Intelligence

   This paper addresses the task of detecting and recognizing human-object interactions (HOI) in images. Considering the intrinsic complexity and structural nature of the task, we introduce a cascaded parsing network (CP-HOI) for a multi-stage, structured HOI understanding. At each cascade stage, an instance detection module progressively refines HOI proposals and feeds them into a structured interaction reasoning module. Each of the two ...

   Journal Article

4. High-Accuracy Ranging and Localization With Ultrawideband Communications for Energy-Constrained Devices 

   Flueratoru L.; Wehrli S.; Magno M.; et al. (2022)

   IEEE Internet of Things Journal

   Ultrawideband (UWB) communications have gained popularity in recent years for being able to provide distance measurements and localization with high accuracy, which can enhance the capabilities of devices in the Internet of Things (IoT). Since energy efficiency is of utmost concern in such applications, in this work, we evaluate the power and energy consumption, distance measurements, and localization performance of two types of UWB ...

   Journal Article

5. Envelope modulated x-ray grating interferometry 

   Pandeshwar A.; Kagias M.; Shi Z.; et al. (2022)

   Applied Physics Letters

   X-ray dark-field and phase contrast imaging using grating interferometry (GI) have demonstrated great potential for medical and industrial applications. GI relies on the fabrication of high-quality absorption gratings, which has revealed to be quite challenging. This paper proposes an interferometer for dark-field and differential phase contrast imaging using a single phase-shifting element. This proposal simplifies the setup without ...

   Journal Article

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