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Effective-inductance-change based magnetic particle sensing
(2015)The invention relates to an integrated measurement system to detect a quantity of magnetic particles in a sample. The measurement system includes a substrate. An electromagnetic (EM) structure disposed on the surface of the substrate is configured to receive a sample including the magnetic particles in proximity thereof. The integrated measurement system also includes an electrical current generator disposed on the surface of the substrate ...Patent -
Electromagnetic molecular sensors and methods of using same
(2015)Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors, and a binding moiety. The device can include an electromagnetic material that can be detected by the detector. The device is configured such that binding of an analyte to the binding moiety changes the relationship between the electromagnetic ...Patent -
Ultrasensitive detection platform for sensing magnetic and/or electrical energy change
(2014)A scalable and ultrasensitive frequency-shift magnetic array scheme. The theoretical limit of the sensor noise floor is shown to be dominated by the phase noise of the sensing oscillators. To increase the sensitivity, a noise suppression technique, Correlated Double Counting (CDC), is described with no power overhead. As an implementation example, a 64-cell sensor array is designed in a standard 65 nm CMOS process. The CDC scheme achieves ...Patent -
Noise suppression techniques in high precision long-term frequency/timing measurements
(2013)A frequency/timing measurement apparatus includes a reference source having a reference source output terminal. At least one target source has a target source output terminal. The at least one target source is communicatively coupled to the reference source. A frequency timing measurement block has a first input terminal electrically coupled to the reference source output terminal. A second input terminal is electrically coupled to the ...Patent -
Frequency-shift CMOS magnetic biosensor array with single bead sensitivity and no external magnet
(2013)According to one aspect, an integrated magnetic particle measurement device for detecting a presence or absence of magnetic particles in a sample volume includes at least one sensor cell having a differential sensor pair. An active sensor oscillator frequency is responsive to one or more magnetic particles situated within a sample volume. The sensor cell is configured to be operative in the absence of an externally applied magnetic field. ...Patent -
Broadband phase synthesis network with self-healing capability
(2013)A phase synthesis network having self healing capability. The phase synthesis network includes two phase rotators that receive I and Q input LO signals, that receive a digital control signal, and that can adjust a phase and a gain in response to the digital control signal. An output of each of the phase rotators provides a respective output signal to a switch. The switch provides a selected one of the respective output signals for mixing ...Patent -
Electronic self-healing methods for radio-frequency receivers
(2012)Systems and methods for providing self-healing integrated circuits. The method is characterized in that the behavior of a circuit or a device in response to an input signal is observed. One or more operational parameters or characteristics of the circuit or the device are derived. A corrective action to bring the operational parameters or characteristics of the circuit or device within a desired range is deduced, if needed. The corrective ...Patent -
Fully integrated temperature regulator for biochemical applications
(2012)The invention is an integrated temperature regulator that can be fabricated using conventional semiconductor processing technology. The integrated temperature regulator can include a reaction chamber, for example fabricated from PDMS, in which chemical or biochemical reactions of interest can be carried out. The temperature regular can also be used to regulate the temperature of some circuits, e.g. an effective-inductance-change based ...Patent -
Cell-based sensing systems and methods
(2012)The present disclosure describes cell-based sensors. Cell-based sensors can comprise cells coupled with a sensor for sensing change of configuration and/or movement of the cells. Such changes of configuration and/or movement of the cells can be sensed through changes to one or more parameters such as electrical, mechanical and/or optical parameters. By way of example, the sensors can be magnetic based sensors or electrochemical sensors.Patent