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Fictions of Systematicity: Maimon’s quest for a scientific method in philosophy
(2021)Philosophers’ ImprintThis paper argues that Maimon’s metaphilosophy presents a distinctive view on what the scientific role and method of philosophy should consist in: in the production of fictions of systematicity. It shows how Maimon’s philosophy of science links to metaphilosophical views, and ultimately leads him to adopt the so-called “method of fictions” to transform philosophy into a proper science. By connecting his remarks on scientific fictions and ...Journal Article -
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
(2010)Molecular Systems BiologyAssembly of a transcriptional and post-translational molecular interaction network in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex ...Journal Article -
The Roman amphitheatre in mérida, Spain -Augustan or Flavian? Radiocarbon dating results on mortar carbonate
(2020)GeochronometriaFour lime mortar samples from the Mérida amphitheatre in Spain were dated in 2001 and re-dated in 2019 with refined dating methods and focus on carbon dioxide that was released in late CO2 fractions when dissolved in phosphoric acid. The samples were difficult to date because they contained highly soluble, young carbonate contamination that dominated the carbon dioxide from the early stages of the reaction with the acid in the hydrolysis ...Journal Article -
Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
(2022)Journal of Visualized Experiments. JoVECell therapy has long been an emerging treatment paradigm in experimental neurobiology. However, cell transplantation studies often rely on end-point measurements and can therefore only evaluate longitudinal changes of cell migration and survival to a limited extent. This paper provides a reliable, minimally invasive protocol to transplant and longitudinally track neural progenitor cells (NPCs) in the adult mouse brain. Before transplantation, ...Journal Article -
Crystal structure of 2-[6-(2-formylphenoxy)-2,4-hexadiynyloxy]-benzaldehyde,C20H14O4
(2006)Zeitschrift für Kristallographie. New Crystal StructuresJournal Article -
Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action
(2010)Molecular Systems BiologyWe present a cross-species chemogenomic screening platform using libraries of haploid deletion mutants from two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We screened a set of compounds of known and unknown mode of action (MoA) and derived quantitative drug scores (or D-scores), identifying mutants that are either sensitive or resistant to particular compounds. We found that compound–functional module relationships ...Journal Article -
Application of mouse parthenogenetic haploid embryonic stem cells as a substitute of sperm
(2020)Journal of Visualized Experiments. JoVEIn organisms with sexual reproduction, germ cells are the source of totipotent cells that develop into new individuals. In mice, fertilization of an oocyte by a spermatozoon creates a totipotent zygote. Recently, several publications have reported that haploid embryonic stem cells (haESCs) can be a substitute for gametic genomes and contribute to embryos, which develop into mice. Here, we present a protocol to apply parthenogenetic haESCs ...Journal Article -
Pyricularia graminis-tritici, a new Pyricularia species causing wheat blast
(2016)Persoonia - Molecular Phylogeny and Evolution of FungiPyricularia oryzae is a species complex that causes blast disease on more than 50 species of poaceous plants. Pyricularia oryzae has a worldwide distribution as a rice pathogen and in the last 30 years emerged as an important wheat pathogen in southern Brazil. We conducted phylogenetic analyses using 10 housekeeping loci for 128 isolates of P. oryzae sampled from sympatric populations of wheat, rice, and grasses growing in or near wheat ...Journal Article -
Genome-scale phylogenies reveal relationships among Parastagonospora species infecting domesticated and wild grasses
(2021)PersooniaSeveral plant pathogenic Parastagonospora species have been identified infecting wheat and other cereals over the past 50 years. As new lineages were discovered, naming conventions grew unwieldy and the relationships with previously recognized species remained unclear. We used genome sequencing to clarify relationships among these species and provided new names for most of these species. Six of the nine described Parastagonospora species ...Journal Article -
Risk Governance and Vulnerability Factors of Critical Infrastructure
(2017)Russian Digital Libraries JournalOn example of recent multi-risk disasters and their impacts on electricity transmission grids this paper shows the need of multi-risk assessment and governance. It discusses factors of vulnerability of electricity transmission infrastructure in Europe in lights of changing for architecture of electricity grids requirements, growing volumes of renewable energy sources and probabilities for cascading effects. The paper also brings examples ...Journal Article