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Moving Universities: A Case Study on the Use of Unconferencing for Facilitating Sustainability Learning in a Swiss University
(2011)SustainabilityUnconferencing is a method for organizing social learning which could be suitable to trigger sustainability learning processes. An unconference is defined as participant-driven meeting that tries to avoid one or more aspects of a conventional conference, such as top-down organization, one-way communication and power-relationships based on titles, formal hierarchies and status. This paper presents a case study on the application of ...Journal Article -
Target Profile Prediction and Practical Evaluation of a Biginelli-Type Dihydropyrimidine Compound Library
(2011)PharmaceuticalsWe present a self-organizing map (SOM) approach to predicting macromolecular targets for combinatorial compound libraries. The aim was to study the usefulness of the SOM in combination with a topological pharmacophore representation (CATS) for selecting biologically active compounds from a virtual combinatorial compound collection, taking the multi-component Biginelli dihydropyrimidine reaction as an example. We synthesized a candidate ...Journal Article -
Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields
(2011)British Journal of CancerBackground: Therapeutic options for patients with advanced hepatocellular carcinoma (HCC) are limited. There is emerging evidence that the growth of cancer cells may be altered by very low levels of electromagnetic fields modulated at specific frequencies. Methods: A single-group, open-label, phase I/II study was performed to assess the safety and effectiveness of the intrabuccal administration of very low levels of electromagnetic ...Journal Article -
Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture
(2011)The EMBO JournalJournal Article -
Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila
(2011)mBioProteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence. The role of cyclic diguanylate signaling in the lifestyle of Legionella pneumophila, the causative agent of Legionnaires’ disease, has not previously been examined. The L. pneumophila genome encodes ...Journal Article -
Screening of Escherichia coli species biodiversity reveals new biofilm-associated antiadhesion polysaccharides
(2011)mBioBacterial biofilms often form multispecies communities in which complex but ill-understood competition and coop-eration interactions occur. In light of the profound physiological modifications associated with this lifestyle, we hypothesizedthat the biofilm environment might represent an untapped source of natural bioactive molecules interfering with bacterial adhe-sion or biofilm formation. We produced cell-free solutions extracted fromin ...Journal Article -
Analysis of the “Sonar Hopf” Cochlea
(2011)SensorsThe “Sonar Hopf” cochlea is a recently much advertised engineering design of an auditory sensor. We analyze this approach based on a recent description by its inventors Hamilton, Tapson, Rapson, Jin, and van Schaik, in which they exhibit the “Sonar Hopf” model, its analysis and the corresponding hardware in detail. We identify problems in the theoretical formulation of the model and critically examine the claimed coherence between the ...Journal Article -
Determination of Jet Energy Calibration and Transverse Momentum Resolution in CMS
(2011)Journal of InstrumentationMeasurements of the jet energy calibration and transverse momentum resolution in CMS are presented, performed with a data sample collected in proton-proton collisions at a centre-of-mass energy of 7TeV, corresponding to an integrated luminosity of 36pb−1. The transverse momentum balance in dijet and γ/Z+jets events is used to measure the jet energy response in the CMS detector, as well as the transverse momentum resolution. The results ...Journal Article -
Controlled vocabularies and semantics in systems biology
(2011)Molecular Systems BiologyThe use of computational modeling to describe and analyze biological systems is at the heart of systems biology. Model structures, simulation descriptions and numerical results can be encoded in structured formats, but there is an increasing need to provide an additional semantic layer. Semantic information adds meaning to components of structured descriptions to help identify and interpret them unambiguously. Ontologies are one of the ...Journal Article -
Absolute quantification of microbial proteomes at different states by directed mass spectrometry
(2011)Molecular Systems BiologyOver the past decade, liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) has evolved into the main proteome discovery technology. Up to several thousand proteins can now be reliably identified from a sample and the relative abundance of the identified proteins can be determined across samples. However, the remeasurement of substantially similar proteomes, for example those generated by perturbation experiments in systems ...Journal Article