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Engineering fibronectin-templated multi-component fibrillar extracellular matrices to modulate tissue-specific cell response
(2024)BiomaterialsCells assemble fibronectin, the major extracellular matrix (ECM) protein, into fibrillar matrices, which serve as 3D architectural scaffolds to provide, together with other ECM proteins tissue-specific environments. Although recent approaches enable to bioengineer 3D fibrillar fibronectin matrices in vitro, it remains elusive how fibronectin can be co-assembled with other ECM proteins into complex 3D fibrillar matrices that recapitulate ...Journal Article -
Effects of climate, socioeconomic development, and greening governance on enhanced greenness under urban densification
(2024)Resources, Conservation and RecyclingUrban vegetation is essential for the quality of life in cities. Despite direct vegetation loss during urban expansion, urbanization can indirectly enhance vegetation greening through various factors. Yet, it remains unclear what conditions promoted these greening trends within cities. We quantified the greenness trends in 294 Chinese cities based on satellite imagery (2001–2018), which we then explained with climate and socioeconomic ...Journal Article -
Dual configuration of shallow acceptor levels in 4H-SiC
(2024)Materials Science in Semiconductor ProcessingAcceptor dopants in 4H-SiC exhibit energy levels that are located deeper in the band gap than the thermal energy at room temperature (RT), resulting in incomplete ionization at RT. Therefore, a comprehensive understanding of the defect energetics and how the impurities are introduced into the material is imperative. Herein, we study impurity related defect levels in 4H-SiC epitaxial layers (epi-layers) grown by chemical vapor deposition ...Journal Article -
Fibre reinforced PET composite manufacturing via Solid State Polymerisation
(2024)Composites Part A: Applied Science and ManufacturingDue to the high viscosity of thermoplastics, their processing in fibre-reinforced composite is not trivial. Here we present a route to obviate this issue in a solvent-free manner. To this purpose, we impregnate GF textiles with low-viscosity PET polymer followed by in-situ solid state polymerisation. Processing at low viscosity enables time-efficient manufacturing of void-free intermediate materials, followed by a post-processing step in ...Journal Article -
Numerical investigation of crack propagation regimes in snow fracture experiments
(2024)Granular MatterA snow slab avalanche releases after failure initiation and crack propagation in a highly porous weak snow layer buried below a cohesive slab. While our knowledge of crack propagation during avalanche formation has greatly improved over the last decades, it still remains unclear how snow mechanical properties affect the dynamics of crack propagation. This is partly due to a lack of non-invasive measurement methods to investigate the ...Journal Article -
Experimental Study of the Earth Pressure Evolution on a Model Wall Rotating about Its Base
(2024)Journal of Geotechnical and Geoenvironmental EngineeringQuantifying the earth pressure acting on retaining structures is essential for a number of engineering applications, including the assessment of damaged structures. In response to the widespread corrosion found in many cantilever retaining walls in Switzerland, this study investigates the evolution of the earth pressure acting on a retaining wall rotating about its base: The dominant deformation mode for such structures. In a controlled ...Journal Article -
Self-optimizing method and software for calibration and mapping of a laser system for laser machining
(2024)Optics and Lasers in EngineeringShort and ultrashort pulse lasers can ablate the vast majority of materials compared to other machining methods, making them the preferred tool in many niche applications. For the use in precision machining, such laser systems need to reach machining accuracy in the range of 1 µm. Usually, a galvanometric scanner is used in such laser systems to scan the laser beam across the scan field to mark or ablate the various materials. To achieve ...Journal Article -
Development and validation of a clinical decision support system to prevent anticoagulant duplications
(2024)International Journal of Medical InformaticsBackground and Objective: Unintended duplicate prescriptions of anticoagulants increase the risk of serious adverse events. Clinical Decision Support Systems (CDSSs) can help prevent such medication errors; however, sophisticated algorithms are needed to avoid alert fatigue. This article describes the steps taken in our hospital to develop a CDSS to prevent anticoagulant duplication (AD). Methods: The project was composed of three phases. ...Journal Article -
Design Space Exploration and Explanation via Conditional Variational Autoencoders in Meta-Model-Based Conceptual Design of Pedestrian Bridges
(2024)Automation in ConstructionToday, engineers rely on conventional iterative (often manual) techniques for conceptual design. Emerging parametric models facilitate design space exploration based on quantifiable performance metrics, yet remain time-consuming and computationally expensive, leaving room for improvement. This paper provides a design exploration and explanation framework to augment the designer via a Conditional Variational Autoencoder (CVAE), which serves ...Journal Article -
Marginal integrity in minimally invasive molar resin composite restorations: Impact of polymerization shrinkage
(2024)Journal of the Mechanical Behavior of Biomedical MaterialsObjectives: This study utilized non-linear finite element (FE) models to explore polymerization shrinkage and its impact on marginal integrity in molars following both selective caries removal (SCR) and conventional treatment. Specifically, we performed 2D in silico simulations to study residual stresses post-resin polymerization shrinkage and their influence on the marginal integrity of various restoration types. Methods: Initially, FE ...Journal Article