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Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response
(2011)Nature CommunicationsActivin is an important orchestrator of wound repair, but its potential role in skin carcinogenesis has not been addressed. Here we show using different types of genetically modified mice that enhanced levels of activin in the skin promote skin tumour formation and their malignant progression through induction of a pro-tumourigenic microenvironment. This includes accumulation of tumour-promoting Langerhans cells and regulatory T cells in ...Journal Article -
No extension of quantum theory can have improved predictive power
(2011)Nature CommunicationsAccording to quantum theory, measurements generate random outcomes, in stark contrast with classical mechanics. This raises the question of whether there could exist an extension of the theory that removes this indeterminism, as suspected by Einstein, Podolsky and Rosen. Although this has been shown to be impossible, existing results do not imply that the current theory is maximally informative. Here we ask the more general question of ...Journal Article -
Measuring single-nanoparticle wetting properties by freeze-fracture shadow-casting cryo-scanning electron microscopy
(2011)Nature CommunicationsNanoparticles at fluid interfaces are central to a rapidly increasing range of cutting-edge applications, including drug delivery, uptake through biological membranes, emulsion stabilization and the fabrication of nanocomposites. Understanding nanoscale wetting is a challenging issue, still unresolved for individual nanoparticles, and is essential in designing nanoparticle-building blocks with controlled surface properties. The core ...Journal Article -
Missing transverse energy performance of the CMS detector
(2011)Journal of InstrumentationDuring 2010 the LHC delivered pp collisions with a centre-of-mass energy of 7 TeV. In this paper, the results of comprehensive studies of missing transverse energy as measured by the CMS detector are presented. The results cover the measurements of the scale and resolution for missing transverse energy, and the effects of multiple pp interactions within the same bunch crossings on the scale and resolution. Anomalous measurements of missing ...Journal Article -
Modularity and hormone sensitivity of the Drosophila melangaster insulin receptor/target of rapamycin interaction proteome
(2011)Molecular Systems BiologyGenetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target of rapamycin (InR/TOR) pathway. However, the biochemical context of this regulatory system is still poorly characterized in Drosophila. Here, we present the first quantitative study that systematically characterizes ...Journal Article -
RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42
(2011)Molecular Systems BiologyThe pathogen Salmonella Typhimurium is a common cause of diarrhea and invades the gut tissue by injecting a cocktail of virulence factors into epithelial cells, triggering actin rearrangements, membrane ruffling and pathogen entry. One of these factors is SopE, a G‐nucleotide exchange factor for the host cellular Rho GTPases Rac1 and Cdc42. How SopE mediates cellular invasion is incompletely understood. Using genome‐scale RNAi screening ...Journal Article -
Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template
(2011)Molecular Systems BiologyNatural and synthetic biological networks must function reliably in the face of fluctuating stoichiometry of their molecular components. These fluctuations are caused in part by changes in relative expression efficiency and the DNA template amount of the network‐coding genes. Gene product levels could potentially be decoupled from these changes via built‐in adaptation mechanisms, thereby boosting network reliability. Here, we show that a ...Journal Article -
A Meta Analysis on Farm-Level Costs and Benefits of GM Crops
(2011)SustainabilityThis paper reviews the evidence on the socio-economic impacts of GM crops and analyzes whether there are patterns across space and time. To this end, we investigate the effect of GM crops on farm-level costs and benefits using global data from more than one decade of field trials and surveys. More specifically, we analyze the effects of GM-crops on crop yields, seed costs, pesticide costs, and management and labor costs and finally gross ...Journal Article