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Identification and Evaluation of Improved 4′-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics
(2014)mBioThe emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight ofcurrent research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rational syn-thesis focusing on 4=alkylations of the aminoglycoside paromomycin, with the goal to alleviate the most severe and disablingside effect of aminoglycosides—irreversible hearing loss. Compounds were ...Journal Article