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Transcriptional regulation is insufficient to explain substrate‐induced flux changes in Bacillus subtilis
(2013)Molecular Systems BiologyOne of the key ways in which microbes are thought to regulate their metabolism is by modulating the availability of enzymes through transcriptional regulation. However, the limited success of efforts to manipulate metabolic fluxes by rewiring the transcriptional network has cast doubt on the idea that transcript abundance controls metabolic fluxes. In this study, we investigate control of metabolic flux in the model bacterium Bacillus ...Journal Article