Search
Results
-
Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells
(2024)Journal of Visualized Experiments. JoVEInfections, autoimmune diseases, desired and adverse immunological responses to treatment can lead to a complex and dynamic cytokine response in vivo. This response involves numerous immune cells secreting various cytokines to orchestrate the immune reaction. However, the secretion dynamics, amounts, and co-occurrence of the different cytokines by various cell subtypes remain poorly understood due to a lack of appropriate tools to study ...Journal Article -
Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair
(2024)Journal of Visualized Experiments. JoVETendons enable locomotion by transferring muscle forces to bones. They rely on a tough tendon core comprising collagen fibers and stromal cell populations. This load-bearing core is encompassed, nourished, and repaired by a synovial-like tissue layer comprising the extrinsic tendon compartment. Despite this sophisticated design, tendon injuries are common, and clinical treatment still relies on physiotherapy and surgery. The limitations ...Journal Article -
Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
(2022)Journal of Visualized Experiments. JoVECell therapy has long been an emerging treatment paradigm in experimental neurobiology. However, cell transplantation studies often rely on end-point measurements and can therefore only evaluate longitudinal changes of cell migration and survival to a limited extent. This paper provides a reliable, minimally invasive protocol to transplant and longitudinally track neural progenitor cells (NPCs) in the adult mouse brain. Before transplantation, ...Journal Article -
Sequential Bayesian Inference for Uncertain Nonlinear Dynamic Systems: A Tutorial
(2022)Journal of Structural DynamicsIn this article, an overview of Bayesian methods for sequential simulation from posterior distributions of nonlinear and non-Gaussian dynamic systems is presented. The focus is mainly laid on sequential Monte Carlo methods, which are based on particle representations of probability densities and can be seamlessly generalized to any state-space representation. Within this context, a unified framework of the various Particle Filter (PF) ...Journal Article -
Integration of piezoelectric stacks in components using powder bed fusion
(2022)Smart Materials and StructuresLaser-based powder bed fusion of metals (PBF-LB/M) is the most commonly used additive manufacturing process for fabricating complex metal parts by selective, layer-wise melting of metallic powder using a laser beam. This manufacturing technique can easily fabricate parts with complex geometries that cannot be fabricated using conventional manufacturing processes. These parts with complex geometries are generally used by aerospace and space ...Journal Article -
Fictions of Systematicity: Maimon’s quest for a scientific method in philosophy
(2021)Philosophers’ ImprintThis paper argues that Maimon’s metaphilosophy presents a distinctive view on what the scientific role and method of philosophy should consist in: in the production of fictions of systematicity. It shows how Maimon’s philosophy of science links to metaphilosophical views, and ultimately leads him to adopt the so-called “method of fictions” to transform philosophy into a proper science. By connecting his remarks on scientific fictions and ...Journal Article -
Quaternary Structure Modeling Through Chemical Cross-Linking Mass Spectrometry: Extending TX-MS Jupyter Reports
(2021)Journal of Visualized Experiments. JoVEProtein-protein interactions can be challenging to study yet provide insights into how biological systems function. Targeted cross-linking mass spectrometry (TX-MS), a method combining quaternary protein structure modeling and chemical cross-linking mass spectrometry, creates high-accuracy structure models using data obtained from complex, unfractionated samples. This removes one of the major obstacles to protein complex structure analysis ...Journal Article -
CrowdNotifier: Decentralized Privacy-Preserving Presence Tracing
(2021)Proceedings on Privacy Enhancing TechnologiesThere is growing evidence that SARS-CoV-2can be transmitted beyond close proximity contacts, in particular in closed and crowded environments with in-sufficient ventilation. To help mitigation efforts, contact tracers need a way to notify those who were present in such environments at the same time as infected individuals. Neither traditional human-based contact tracing powered by handwritten or electronic lists, norBluetooth-enabled ...Journal Article -
Comparative Test Program Framework for Non-SF6 Switching Gases
(2021)B&H Electrical EngineeringIn recent years, significant achievements have been made with respect to the development of SF6-free gas insulated substations (GIS). In parallel, the interest in installing SF6-free GIS by utilities increased steadily and tenders for new substations or upgrades regularly also include alternative technologies. The excellent performance of SF6 was unequivocally accepted by all vendors and users so that the community became used to single ...Journal Article -
Mapping of Fabry-Perot and Whispering Gallery Modes in GaN microwires by Nonlinear imaging
(2021)NanotechnologyEngineering nonlinear optical responses at the microscale is a key topic in photonics for achieving efficient frequency conversion and light manipulation. Gallium nitride (GaN) is a promising semiconductor material for integrated nonlinear photonic structures. In this work, we use epitaxially grown GaN microwires as nonlinear optical whispering gallery and Fabry-Perot resonators. We demonstrate an effective generation of second-harmonic ...Journal Article