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The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis
(2009)The Journal of Cell BiologyCul3 (Cullin3)-based E3 ubiquitin ligases recently emerged as critical regulators of mitosis. In this study, we identify two mammalian BTB (Bric-a-brac–Tramtrack–Broad complex)-Kelch proteins, KLHL21 and KLHL22, that interact with Cul3 and are required for efficient chromosome alignment. Interestingly, KLHL21 but not KLHL22 is necessary for cytokinesis and regulates translocation of the chromosomal passenger complex (CPC) from chromosomes ...Journal Article -
New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering
(2009)The Journal of Cell BiologyJournal Article -
Yvh1 is required for a late maturation step in the 60S biogenesis pathway
(2009)The Journal of Cell BiologyBefore entering translation, preribosomal particles undergo sequential late maturation steps. In the case of pre-60S particles, these steps involve the release of shuttling maturation factors and transport receptors. In this study, we report a new maturation step in the 60S biogenesis pathway in budding yeast. We show that efficient release of the nucleolar/nuclear ribosomal-like protein Mrt4 (homologous to the acidic ribosomal P-protein ...Journal Article -
Optical Properties of Nitrogen-Substituted Strontium Titanate Thin Films Prepared by Pulsed Laser Deposition
(2009)MaterialsPerovskite-type N-substituted SrTiO3 thin films with a preferential (001) orientation were grown by pulsed laser deposition on (001)-oriented MgO and LaAlO3 substrates. Application of N2 or ammonia using a synchronized reactive gas pulse produces SrTiO3-x:Nx films with a nitrogen content of up to 4.1 at.% if prepared with the NH3 gas pulse at a substrate temperature of 720 °C. Incorporating nitrogen in SrTiO3 results in an optical absorption ...Journal Article -
Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours
(2009)British Journal of CancerBackground: Hypoxia, which is commonly observed in areas of primary tumours and of metastases, influences response to treatment. However, its characterisation has so far mainly been restricted to the ex vivo analysis of tumour sections using monoclonal antibodies specific to carbonic anhydrase IX (CA IX) or by pimonidazole staining, after the intravenous administration of this 2-nitroimidazole compound in experimental animal models. ...Journal Article -
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly
(2009)The Journal of Cell BiologyMitotic spindle formation and chromosome segregation depend critically on kinetochore–microtubule (KT–MT) interactions. A new protein, termed Spindly in Drosophila and SPDL-1 in C. elegans, was recently shown to regulate KT localization of dynein, but depletion phenotypes revealed striking differences, suggesting evolutionarily diverse roles of mitotic dynein. By characterizing the function of Spindly in human cells, we identify specific ...Journal Article -
Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division
(2009)The EMBO JournalJournal Article -
Analysis of Effective Interconnectivity of DegraPol-foams Designed for Negative Pressure Wound Therapy
(2009)MaterialsMany wounds heal slowly and are difficult to manage. Therefore Negative Pressure Wound Therapy (NPWT) was developed where polymer foams are applied and a defined negative pressure removes wound fluid, reduces bacterial burden and increases the formation of granulation tissue. Although NPWT is used successfully, its mechanisms are not well understood. In particular, different NPWT dressings were never compared. Here a poly-ester urethane ...Journal Article -
Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases
(2009)The EMBO JournalJournal Article -
The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity
(2009)EMBO ReportsJournal Article