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The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection
(2013)mBioThe intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining homeostasis. Listeria monocytogenes is the agent of listeriosis, an infection transmitted to humans upon ingestion of contaminated food. Crossing of the intestinal barrier is a critical step of the infection before dissemination ...Journal Article -
SATB1 collaborates with loss of p16 in cellular transformation
(2013)OncogeneTumor progression is associated with invasiveness and metastatic potential. The special AT-rich binding protein 1 (SATB1) has been identified as a key factor in the progression of breast cancer cells to a malignant phenotype and is associated with progression of human tumors. In normal development, SATB1 coordinates gene expression of progenitor cells by functioning as a genome organizer. In contrast to progenitor and tumor cells, SATB1 ...Journal Article -
Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage
(2013)Cell Death and DifferentiationJournal Article -
Frequent floods in the European Alps coincide with cooler periods of the past 2500 years
(2013)Scientific ReportsSevere floods triggered by intense precipitation are among the most destructive natural hazards in Alpine environments, frequently causing large financial and societal damage. Potential enhanced flood occurrence due to global climate change would thus increase threat to settlements, infrastructure, and human lives in the affected regions. Yet, projections of intense precipitation exhibit major uncertainties and robust reconstructions of ...Journal Article -
Prediction Stability in a data-based mechanistic model of σF during sporulation in Bacillus subtilis
(2013)Scientific ReportsMathematical modeling of biological networks can help to integrate a large body of information into a consistent framework, which can then be used to arrive at novel mechanistic insight and predictions. We have previously developed a detailed, mechanistic model for the regulation of σ F during sporulation in Bacillus subtilis. The model was based on a wide range of quantitative data, and once fitted to the data, the model made predictions ...Journal Article -
Pharmacologically Controlled Protein Switch for ON-OFF Regulation of Growth Factor Activity
(2013)Scientific ReportsThe precise manipulation of growth factor signaling is central to the progress of tissue engineering. Methods for direct time-resolved activation of signaling pathways through controlled receptor dimerization have been reported; however, these suffer from the risks associated with gene transfer. Here we present an alternative gene transfer-free approach in the form of a protein switch featuring pharmacologically controlled ON-OFF regulation ...Journal Article -
Characterization of Flexible Copolymer Optical Fibers for Force Sensing Applications
(2013)SensorsIn this paper, different polymer optical fibres for applications in force sensing systems in textile fabrics are reported. The proposed method is based on the deflection of the light in fibre waveguides. Applying a force on the fibre changes the geometry and affects the wave guiding properties and hence induces light loss in the optical fibre. Fibres out of three different elastic and transparent copolymer materials were successfully ...Journal Article -
Potential release scenarios for carbon nanotubes used in composites
(2013)Environment InternationalThe expected widespread use of carbon nanotube (CNT)-composites in consumer products calls for an assessment of the possible release and exposure to workers, consumers and the environment. Release of CNTs may occur at all steps in the life cycle of products, but to date only limited information is available about release of CNTs from actual products and articles. As a starting point for exposure assessment, exploring sources and pathways ...Journal Article -
How Eco-Efficient Are Low-Input Cropping Systems in Western Europe, and What Can Be Done to Improve Their Eco-Efficiency
(2013)SustainabilityLow-input cropping systems were introduced in Western Europe to reduce the environmental impacts of intensive farming, but some of their benefits are offset by lower yields. In this paper, we review studies that used Life Cycle Assessment (LCA) to investigate the effects of reducing external inputs on the eco-efficiency of cropping systems, measured as the ratio of production to environmental impacts. We also review various cropping system ...Journal Article -
Single-cell lysis for visual analysis by electron microscopy
(2013)Journal of Structural BiologyThe stochastic nature of biological systems makes the study of individual cells a necessity in systems biology. Yet, handling and disruption of single cells and the analysis of the relatively low concentrations of their protein components still challenges available techniques. Transmission electron microscopy (TEM) allows for the analysis of proteins at the single-molecule level. Here, we present a system for single-cell lysis under light ...Journal Article