Book Chapter
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Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases
(2025)Methods in Enzymology ~ Genomics-Guided Natural Products DiscoveryPolyketide synthases (PKSs) are multienzyme complexes that produce bioactive compounds with applications in medicine and agriculture. This review focuses on the genome-guided discovery of polyketides synthesized by trans-acyltransferase (trans-AT) PKSs, which, compared with the more prevalent cis-AT PKS counterparts, introduce distinct and complex chemical features that may entail specialized biological activities. With the rapid expansion ...Book Chapter -
Chapter 6: Towards a Political Epistemology of Abstraction: an Inquiry into the Case of Jost Bürgi’s Progress Tabulen (1620)
(2025)Intersections ~ Science and Praxis: Historical Cases of Political EpistemologyIn this article, I present a political conception of abstraction based on cases derived from the history of science. I argue that abstraction emerges from the codification of knowledge gathered in specific social practices. Moreover, its particular way of implementation is guided by and portrays a certain vision for the world. Thereby, abstraction always carries political momentum, the understanding of which is deemed essential to counter ...Book Chapter -
Inherited Antifragility
(2026)SpringerBriefs in Computer Science ~ Applied Antifragility in Technical Systems: From Principles to ApplicationsThis chapter introduces inherited antifragility as a gained characteristic of a technical system. It describes the benefit derived from input distribution unevenness, based on the emergent system dynamics and its interactions with the operating environment (i.e. disturbances, noise), under the premise that the intrinsic dynamics of the system are exposed to the interactions. We consider methods for the detection, analysis, and modelling ...Book Chapter -
Designing an Instructionally Focused Practical Measurement System Centered on Equity
(2025)Continuous Improvement in Education Series ~ Measuring to Improve: Practical Measurement to Support Continuous Improvement in EducationBook Chapter -
Biobased Product Design, Development, and Utilization in the Global South
(2025)Sustainable Bioeconomy Development in the Global SouthThe design, development, and use of biobased economy are required to meet the world’s increasing demand for food, materials, and energy while maintaining biodiversity and the ecological balance of the planet (Lewandowski, 2018; Sharma et al., 2021). Biobased products are often biodegradable and have a lower environmental footprint. They can help reduce greenhouse gas emissions, decrease dependence on fossil fuels, and minimize pollution ...Book Chapter -
Artificial Intelligence: How It Changes the Landscape for Work Design Research and Practice
(2025)Transformative Work Design: Synthesis and New DirectionsThis chapter discusses the implications of emerging technologies, especially artificial intelligence (AI), for work design theory and practice. Emphasizing the urgency for work design experts to join ongoing efforts to proactively shape the future of work, the chapter highlights three streams of literature and the opportunities for work design research and practice arising in each: (1) expand knowledge on the impact of technology on job ...Book Chapter -
Chapter 8: Epistemology and Politics of AI
(2025)Blackwell Companions to Philosophy ~ A Companion to Applied Philosophy of AIWhile much of politics is about making decisions, machine learning is about making predictions. Despite this diverging focus, machine learning is increasingly deployed in politically sensitive fields. This chapter focuses on the tension arising from this deployment. We specifically address the question of whether machine learning-based political decision making can be justified and how this question of justification interrelates with ...Book Chapter -
Risk Measures and Dependence Modeling
(2025)Handbook of Insurance: Volume IIThis chapter provides an introduction and overview about modeling risks in insurance and finance. Besides the problem of adequately modeling individual risks, modeling their possibly complicated interactions and dependencies is challenging from both a theoretical and a practical point of view. Well-known concepts to model risks are presented and their strengths and weaknesses discussed.Book Chapter -
Chapter Seven - Molecular brain imaging of psychedelic action
(2025)International Review of Neurobiology ~ Psychedelics in PsychiatryMolecular brain imaging by positron emission tomography (PET) and single photon emission computer-tomography (SPECT) entails the mapping of the cerebral distribution of radiopharmaceuticals that track physiological processes such as blood perfusion and glucose metabolism, or the abundance in brain of specific molecular targets such as neuroreceptors. PET and SPECT emerged as useful in vivo research technologies in the 1980s, finding early ...Book Chapter -
13. The cost of transforming into an E-Bike City and the resulting change in safety
(2025)The E-Bike City: Designing sustainable streetsWhen thinking about a transition to an E-Bike City, two important factors are safety and construction costs. This subproject estimates the change in safety for cyclists resulting from infrastructure changes in the E-Bike City, and how much it will cost to build the infrastructure necessary for a transition to such a city. We used a machine learning model to quantify the amount of urban road space that needs to be transformed, and historical ...Book Chapter -
14. Estimating choice models for daily schedules
(2025)The E-Bike City: Designing sustainable streetsThis subproject applies the OASIS framework to estimate MATSim’s schedule scoring function parameters, aiming for behaviorally realistic microsimulations. This method uses empirical data and a two-step estimation process, involving choice set generation via Metropolis-Hastings and parameter estimation through discrete choice models. Early results from Swiss data show realistic parameters and highlight the benefit of including start time ...Book Chapter -
5. Street design guidelines
(2025)The E-Bike City: Designing sustainable streetsMunicipal planning authorities seeking to implement the principles of the E-Bike City can refer to this manual for standardized design guidelines. Its structure is aligned with norms issued by the Swiss Association of Road and Transport Officials, Verband der Strassen- und Verkehrsfachleute (VSS).Book Chapter -
2. The E-Bike City as a radical shift toward zero-emission transport: Sustainable? Equitable? Desirable?
(2025)The E-Bike City: Designing sustainable streetsThis think piece discusses current barriers to the rapid decarbonization of transport and ways to overcome them. Policymakers face a set of contradictory goals, leading them to ponder only incremental measures: The need to reduce carbon emissions conflicts with accessibility improvements and the resulting induced traffic. At the same time, the prevention of urban sprawl as a means of promoting sustainable mobility is fundamentally thwarted ...Book Chapter -
3. Effects of an E-Bike City
(2025)The E-Bike City: Designing sustainable streetsAn E-Bike City massively shifts demand away from cars, but not only to bicycles, but also mainly towards public transport. This results in a substantial reduction of CO2 emissions. At the same time, the transport system’s external effects for society become positive, instead of negative, mostly due to the use of more sustainable modes and the greater benefits of physical activity.Book Chapter -
11. Pedaling towards acceptance: Public preferences and cleavages in street transformation policies
(2025)The E-Bike City: Designing sustainable streetsPublic acceptance of the E-Bike City transformation divides along political and lifestyle lines. A first experiment shows left-leaning individuals and frequent cyclists are more supportive, while drivers and right-leaning respondents express fairness and intrusiveness concerns. Ancillary measures like public transport help, but mainly among the supportive. A second experiment using visualized street redesigns reveals that greenery and ...Book Chapter -
1. Urban mobility reimagined: The E-Bike City vision
(2025)The E-Bike City: Designing sustainable streetsBook Chapter -
8. Congestion-informed road space allocation for cars and bicycles
(2025)The E-Bike City: Designing sustainable streetsAlthough being an effective way to increase bicycle usage by enhancing users’ safety and accessibility transport policies aiming to allocate more road space to bicycles often receive strong criticism from the public because of the concern of potential traffic congestion. Therefore, we first evaluate the traffic performance of a bike lane network design using a heuristic algorithm or only based on the accessibility measurement by simulating ...Book Chapter -
10. Sustainability assessment of battery supply chains and externalities in e-bike mobility
(2025)The E-Bike City: Designing sustainable streetsIn the context of the E-Bike City, we assessed the environmental impacts of battery production and material sourcing to better understand the sustainability of electric mobility. Lithium, one of the key battery materials, shows highly variable environmental impacts depending on where and how it is produced, in most cases higher than previously estimated. These differences were integrated into updated emission factors and used to compare ...Book Chapter -
9. Network optimization and multi-target evaluation
(2025)The E-Bike City: Designing sustainable streetsA key component of the E-Bike City project is designing an optimal bike network, which is a multi-objective, combinatorial problem. We develop a mathematical optimization approach based on linear programming to balance the trade-offs between bike and car travel times, and compare our framework with methods from subproject C in chapter 7. Although this approach minimizes travel times by reallocating road space across Zurich, the resulting ...Book Chapter -
6. Multi-scale responsive public transport planning for bi-modal demand
(2025)The E-Bike City: Designing sustainable streetsMicromobility travel modes, such as e-bikes, are becoming increasingly popular. Travel demand is therefore more sensitive to people’s bi-modal travel behavior, with changes in weather conditions causing variations in travel choices. This subproject aims to redesign the transit system to provide passengers with high-quality service and save operating expenses. For demand variations that may lead to high loads and surplus capacity, it is ...Book Chapter