Book Chapter
Recent Submissions
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Global Climate
(2021)Bulletin of the American Meteorological Society ~ Bulletin of the American Meteorological SocietyBook Chapter -
A MALDI-MS Methodology for Studying Metabolic Heterogeneity of Single Cells in a Population
(2020)Methods in Molecular Biology ~ Single Cell MetabolismMass spectrometry based metabolomics is the highly multiplexed, label-free analysis of small molecules such as metabolites or lipids in biological systems, and thus one of the most direct ways to characterize phenotypes. However, the phenotyping of populations with single-cell resolution is a great challenge due to the small number of molecules contained in an individual cell. Here we describe a microarray-based sample preparation workflow ...Book Chapter -
Applications of MicroArrays for Mass Spectrometry (MAMS) in Single-Cell Metabolomics
(2020)Methods in Molecular Biology ~ Single Cell MetabolismThe metabolic network is the endpoint in the flow of information that begins with the "gene" and ends with "phenotype" (observable function) of the cell. Previously, due to the variety of metabolites analyzed inside cells, the metabolomic measurements were performed with samples including multiple cells. Unfortunately, this sampling process may mask important metabolic phenomena, such as cell-to-cell heterogeneity. For these studies, we ...Book Chapter -
Peak of the Iceberg
(2020)The Art of Theoretical BiologyMedical imaging plays a central role in cancer therapy, however scans cannot detect the full extent of infiltrative brain tumors. Post-mortem and histological studies show that tumor cells can be found even 2 cm beyond the tumor outlines visible on the medical scans. Current radiotherapy planning is handling these uncertainties in a rather rudimentary fashionBook Chapter -
Foundational patents in artificial intelligence
(2021)Artificial Intelligence and Intellectual PropertyDespite advocating openness, technology leaders have been patenting artificial intelligence (AI) inventions at an exponentially increasing rate. Patents on foundational techniques with broad applications have the potential to deter innovation in the field, should the privatization of key components of artificial intelligence be used to exclude third-party innovators. This chapter studies patent applications in the US and demonstrates the ...Book Chapter -
Multiplexed Genome Engineering with Cas12a
(2021)Methods in Molecular Biology ~ Mammalian Cell Engineering. Methods and ProtocolsGenome engineering technologies based on CRISPR-Cas systems are fueling efforts to study genotype-phenotype relationships in a high-throughput and multiplexed fashion. While many genome engineering technologies exist and provide a means to efficiently manipulate one or a few genes in a singular context-knockout, inhibition, or activation in a constitutive, conditional, or inducible manner-progress towards engineering complex cellular ...Book Chapter -
Skills for Nonacademic Wildlife and Conservation Careers
(2017)Becoming a Wildlife ProfessionalBook Chapter -
Information In-Formation: Algorithmic Policing and the Life of Data
(2021)Automating Crime Prevention, Surveillance, and Military OperationsMany aspects of law enforcement increasingly rely on algorithmic processing of digital data. In this book chapter, Mareile Kaufmann and CSS’ Matthias Leese foreground the data that feed into algorithms. In bringing together insights gained from empirical studies on predictive policing software, new materialist thinking and approaches about the liveliness of data, the authors conceptualize data as matter that is “in-formation” due to both ...Book Chapter -
"Armand Schulthess: das Modell für meinen Geiser"
(2021)Dokumentation über Armand SchulthessBook Chapter -
Genealogy of Cross-Laminated Timber (CLT)
(2021)CLT Cross-Laminated Timber: Pioneering innovation in massive wood constructionBook Chapter -
Cross-Laminated Timber: Between simplicity and complexity
(2021)CLT Cross-Laminated Timber: Pioneering innovation in massive wood constructionBook Chapter -
Interview with Karl Moser
(2021)CLT Cross-Laminated Timber: Pioneering innovation in massive wood constructionBook Chapter -
Recent Developments in the Emerging Technology of CLT in Japan
(2021)CLT Cross-Laminated Timber: Pioneering innovation in massive wood constructionBook Chapter -
Foreword
(2021)CLT Cross-Laminated Timber: Pioneering innovation in massive wood constructionBook Chapter -
Interview with Pius Schuler
(2021)CLT Cross-Laminated Timber: Pioneering innovation in massive wood constructionBook Chapter -
Interview with Rudolf and Esther Guyer
(2021)CLT Cross-Laminated Timber: Pioneering innovation in massive wood constructionBook Chapter -
Biosynthesis of Glycoconjugate Virus-like Particles (VLPs)
(2021)Methods in Molecular Biology ~ Vaccine Delivery Technology. Methods and ProtocolsThe outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins. To raise a long-lasting and effective immune response against carbohydrate antigens, they generally require covalent attachment to an immunogenic carrier protein-a so-called glycoconjugate vaccine. One hurdle to the development of glycoconjugate vaccines is that carbohydrate antigens remain ...Book Chapter -
Molecular Scaffold Hopping via Holistic Molecular Representation
(2021)Methods in Molecular Biology ~ Protein-Ligand Interactions and Drug DesignMolecular descriptors encode a variety of molecular representations for computer-assisted drug discovery. Here, we focus on the Weighted Holistic Atom Localization and Entity Shape (WHALES) descriptors, which were originally designed for scaffold hopping from natural products to synthetic molecules. WHALES descriptors capture molecular shape and partial charges simultaneously. We introduce the key aspects of the WHALES concept and provide ...Book Chapter