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Optogenetic Regulation and Interrogation of Gene Expression Variability
(2019)Gene expression can exhibit substantial cell-to-cell variability, which partly stems from stochasticity inherent to the transcription process. Nevertheless, its precise regulation is crucial for most biological processes as well as in biotechnological applications. Many of the steps involved in transcriptional regulation are highly dynamic. For example, a variety of transcription factors (TFs) exhibit a pulsatile pattern of activity. ...Doctoral Thesis