Doctoral Thesis
Recent Submissions
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Individual-level variation in the mating system of a self-compatible hermaphrodite
(2017)Reproduction is one of the most basic characteristics of life itself. The specific mode of reproduction profoundly impacts almost all aspects of biology, ranging from the genetic makeup of organisms to their physiology, morphology, behavior, life history and eventually evolution. Understanding variation among individuals in their ability to reproduce has therefore been a central theme in evolutionary biology for a long time. Of particular ...Doctoral Thesis -
The Impact of Cryptocurrencies on the Internet of Things - Insights from Prototypes
(2017)Doctoral Thesis -
Actuation and intervention principles of a smart bed to improve quality of sleep
(2017)Doctoral Thesis -
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Holistic Optimisation of Distributed Multi Energy Systems for Low Carbon Urban Areas
(2017)More than 50% of world population lives in cities which emit almost 80% of global carbon emissions so cities are becoming focal points for low-carbon transformation and actions to mitigate climate change. With the policy objective of reducing greenhouse gas emissions in the power sector by 80 – 95% over the next 30 years, urban energy systems are at the center of these efforts. However, decarbonizing energy systems requires addressing ...Doctoral Thesis -
Structural Insights into Eukaryotic Translation Initiation and Re-Initiation
(2017)During protein synthesis, the genetic information is translated into a sequence of amino acid building blocks that are sequentially attached to each other by a large ribonucleoprotein complex, the ribosome. One triplet of nucleotides translates into one amino acid. The eukaryotic ribosome can be divided into a small (40S) and a large (60S) subunit. Protein translation is initiated on the small ribosomal subunit upon forming a complex ...Doctoral Thesis -
Composite Bamboo and its Application as Reinforcement in Structural Concrete
(2017)The fast pace of development in many developing countries has led to an increased demand for building and construction materials for housing and infrastructure projects. Reinforced concrete is one of the most widely used building materials around the world. Unfortunately the majority of developing countries lack the resources to produce their own steel. Steel is not without alternatives. There is a material substitute that grows in the ...Doctoral Thesis -
Small molecule receptors involved in the metabolic syndrome
(2017)This thesis is concerned with small molecule receptors in the development of the metabolic syndrome. This thesis focuses on the most common small molecule receptor classes, the nuclear receptors and the G-protein coupled receptors (GPCRs). Chapter 1 is concerned with the role of the nuclear receptor Retinoid-related Orphan Receptor γ (RORγ) in mature brown adipocytes. RORγ is known to be involved in adipogenesis in white adipose tissue, ...Doctoral Thesis -
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Molecular Mimicry of Host Sialome by Human Pathogens to exploit Immunoregulatory Siglecs
(2017)This thesis focuses on the characterization of two human-specific pathogens that mimic host sialic acid surface structures to engage human immunoregulatory Siglec receptors. Furthermore, it explores the use of sialic acid and sialic acid-like molecules as tools and therapeutics. The first chapter introduces the different types of sialic acids and their diverse functions in prokaryotes and eukaryotes. It reviews different viral, bacterial, ...Doctoral Thesis -
Generic Programming in Space and Time
(2017)The development of high performance libraries on modern hardware is extremely difficult and often requires reimplementation or retuning with every new processor generation. Program generators that produce such libraries automatically from a high level description are an appealing solution but only few exist to date. The difficulty is in both the design of the generator but also its actual implementation, which often results in an ad-hoc ...Doctoral Thesis -
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Ensemble Kalman Particle Filters for High-Dimensional Data Assimilation
(2017)Data assimilation consists in estimating the state of a system, for example the atmosphere in numerical weather prediction (NWP), by combining information coming from the dynamical laws of the system with a stream of observations. Because of the presence of observational noise and uncertainty in the initial conditions, a probabilistic instead of a deterministic approach is to be preferred. The goal is thus to estimate the time evolution ...Doctoral Thesis -