Doctoral Thesis
Recent Submissions
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Resiliente Demokratie
(2024)This thesis analyses the normative relationship between the stability of a democratic system, its legitimacy, and political inclusion and exclusion. It starts from the premise that the ideal of equality of opportunity and the autonomous realisation of one's own concept of the good life can only be achieved within a stable democracy. The question is therefore (a) under what conditions people are able and willing to organise their lives ...Doctoral Thesis -
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Cost-efficient Hyperspectral Imaging Methods with Deep Learning
(2024)Hyperspectral images (HSIs) are useful in numerous domains. The key obstacle to fully unleashing the potential of HSIs is the challenge of data acquisition -- acquiring HSIs of high spatial and high spectral resolution at a high frame rate is a grand challenge. This thesis addresses the challenge from two perspectives: 1) developing data-efficient HSI super-resolution (SR) methods and 2) developing a single-shot hyperspectral imaging ...Doctoral Thesis -
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Magnetically responsive bacteria as living therapeutics for cancer treatment
(2024)Doctoral Thesis -
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A Variational Data Assimilation Approach for Stationary Turbulent Flow Simulations
(2024)Computational fluid dynamics based on the Reynolds-averaged Navier--Stokes (RANS) equations provides a robust framework for analyzing complex flow phenomena at manageable computational costs. Despite their widespread use, RANS models inherently yield only averaged quantities and rely on turbulence models, such as the linear eddy viscosity (LEV) models, which introduce uncertainties into the simulations. Experimental flow analysis, while ...Doctoral Thesis -
Structural and Functional Studies of Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3
(2024)The liver plays a crucial role in numerous physiological processes, including blood detoxification and the maintenance of body homeostasis. Hepatocytes have evolved a complex enzymatic molecular machinery specializing in converting hydrophobic molecules into hydrophilic metabolites, which is a critical process for drug pharmacokinetics. Hepatic transporters are essential for the influx and efflux of drugs and their metabolites across cell ...Doctoral Thesis -
Rayleigh-Taylor turbulence with mean shear and interface tension
(2024)Rayleigh-Taylor (RT) turbulence originates at the interface between two fluid layers in the presence of an unstable density stratification \citep{rayleigh1882investigation,taylor1950instability,fermi1953taylor}. In nature, RT turbulence is usually influenced by additional factors. Firstly, the two fluid layers may move at different velocities in the horizontal direction so that a mean shear compounds the unstable density profile. Secondly, ...Doctoral Thesis -
Understanding Supported Bimetallic Nanoparticle Catalysts From First Principles Calculations – Why Both Structure and Dynamics Matter
(2023)Copper-based alloy nanoparticles can efficiently hydrogenate both carbon monox- ide (CO) and carbon dioxide (CO2) to methanol, an important feedstock chemical and a potential fuel for the transition towards a sustainable economy. But the structures of these Copper-based alloy nanoparticle catalysts and the role of each individual component in the catalysts is difficult to understand due to a wide variety of possible active structures ...Doctoral Thesis -
Effects of creep on the interaction between TBM, lining and rock
(2024)Mechanised tunnelling through squeezing ground is very demanding because the space available to accommodate ground deformations is limited. If the converging ground closes the shield gap in the machine area, a pressure starts to develop upon the shield and the tunnel boring machine (TBM) might get stuck. Behind the machine, if ground deformations are prevented by a stiff lining, a prohibitively high rock pressure develops, and the lining ...Doctoral Thesis -
Kinetic Field Theory: a new formalism for microscopic perturbation theory
(2024)This thesis provides a general construction of the Kinetic Field Theory (KFT) framework and its microscopic perturbation theory for any classical physical system which can be described by a Hamiltonian. The generating functional of KFT is constructed based on a definition of phase space in terms of the cotangent bundle of configuration space and utilizing methods borrowed from the path integral formulation of classical mechanics. From it, ...Doctoral Thesis -
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Sweet answers to the decades-long debates on the sucrose retardation
(2024)In the cement and concrete industry, the use of chemical admixtures is essential to improve either the properties for fresh pastes or the hardened concrete. However, many chemical admixtures cause cement hydration retardation in addition to their main effects. Among them, sugars are a family of retards which work specifically to extend the open time by delaying the onset of cement hydration. According to early studies, sucrose is a very ...Doctoral Thesis -
Luftgelagerte Spindel mit aktivem magnetischem Aktuator
(2024)Die Mikrosystemtechnik stellt hohe Anforderungen an die Fertigungsindustrie, insbesondere hinsichtlich der Realisierung kleiner Strukturen mit hoher Präzision und hoher Produktionsrate. Die Gewährleistung dieser Anforderungen erfordert präzise Komponenten, wobei insbesondere aerostatische Lager und mechatronische Elemente eine herausragende Rolle bei der Entwicklung hochpräziser Werkzeugmaschinenspindeln spielen. Diese Arbeit widmet ...Doctoral Thesis -
Bispecific Antibodies for the Treatment of Colorectal Cancer
(2024)Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths globally, resulting in about one million people dying from it each year. At the time of diagnosis, most CRC cases are in an advanced stage, often with the cancer already spread to other organs. The current standard of care for these patients provides limited benefit, which is reflected in a 5-year survival rate of only 14%. This highlights the urgent medical ...Doctoral Thesis -
Modes of fitness increase during the aggregative multicellular development program of Myxococcus xanthus
(2024)In nature, environmental conditions are in constant flux. Organisms must dynamically respond and adapt to the presence of other biological entities as well as abiotic factors in order to survive and reproduce. Both cooperative and competitive interactions between organisms are common. Cooperation involves the expression of a trait that enhances the fitness of other individuals, and usually is costly to express. Conflict arises when the ...Doctoral Thesis