Doctoral Thesis
Recent Submissions
-
MILLIMETER-SCALE SEISMOLOGY: IN-VIVO RESULTS FOR MEDICAL ULTRASOUND
(2024)Waves are excellent carriers of information. By analysing recorded wave- fields, this information can be extracted and harnessed to learn about the internal characteristics of the propagation medium. As they travel through space and time, waves span many orders of magnitude, which has lead to the extensive study of wave phenomena in many fields of science, including seismology and medical ultrasound. In both fields, a primary interest ...Doctoral Thesis -
Machine Learning for Biomedical Applications: From Clinical Complications to PCR Bias
(2024)In an era where machine learning~(ML) are reshaping the landscape of biomedical research, this thesis presents a series of integrated studies that demonstrate the profound impact of ML in tackling complex challenges within related applications. The research undertaken in this thesis spans from improving predictive analytics in medical informatics to advancing data interpretation methods in biotechnological research, thus setting a trajectory ...Doctoral Thesis -
Development of synthetic uptake systems for new-to-nature molecules in Escherichia coli
(2024)Doctoral Thesis -
Towards Bio-Based Delignified Wood-Reinforced Composites with Aqueous Matrix Systems
(2024)Mitigation of global warming requires a paradigm shift in many industries. In this context, one essential step is the development and utilization of more sustainable and renewable materials. Wood, a naturally abundant resource, plays a pivotal role in this transition due to its carbon-sequestering capacity and renewable nature. Wood serves a diverse array of applications, ranging from construction materials to the production of chemical ...Doctoral Thesis -
Cutaneous and immune effects of photochemical-based vaccination in mice
(2024)Vaccination is the medical intervention with perhaps the strongest impact on human health. Conventional vaccines have successfully prevented infectious diseases for more than a century by inducing long-lasting immune responses. Research and development during the last decades have shown that also cancer can be treated by engaging the immune system. However, while the immune system efficiently recognizes foreign protein antigens on pathogens, ...Doctoral Thesis -
From stress field heterogeneity to hydraulic stimulation mechanisms: Insights from a hectometer-scale fractured rock mass
(2024)Hydraulic stimulation is a commonly used technique to enhance the permeability of rock formations, especially in the field of deep geothermal energy. However, a significant drawback of this technique is the occurrence of induced seismic events. Meso-scale (decameter to hectometer) experiments have proven indispensable to overcome this challenge and understand the complex interplay between seismic, hydraulic, and mechanical processes during ...Doctoral Thesis -
Using advanced imaging and profiling technologies to map starch biosynthesis in barley endosperm
(2024)Plants synthesise starch through the polymerisation of simple sugars resulting in water-insoluble granules with diverse morphologies influenced by biological origin, cellular location and environmental factors. Starch is present as transitory starch in chloroplasts through photosynthesis and as storage starch in the amyloplasts of seeds and tubers, with different morphologies. Cereal grains such as barley (Hordeum vulgare L.) store starch ...Doctoral Thesis -
Unsupervised Image Restoration with Deep Learning
(2024)The need for high-quality images is paramount in various applications to enable the extraction of detailed information effectively. For instance, superior magnetic resonance images (MRIs) are crucial for precise anatomical analyses, while high-quality microscopy images are essential for meticulous monitoring of biological processes. However, images are frequently captured at suboptimal quality due to time constraints or are degraded by ...Doctoral Thesis -
-
Peptide barcodes as novel reporters of microRNA activity in mammalian cells
(2024)Studying mammalian gene expression regulation using reporter gene assays has significantly benefited from the advent of high-throughput technologies like next-generation sequencing, enabling the rapid characterization of regulatory mechanisms affecting the cell’s transcriptome. In contrast, studying protein-level regulation has been hampered by the low throughput and high costs of conventional functional assays. Fluorescence-based ...Doctoral Thesis -
Epidemiology, virulence evolution, population genetic and genomic analyses of Cercospora beticola
(2024)Doctoral Thesis -
Geochemical, Isotopic and Experimental Investigations of Differentiation Mechanisms in Arc Magmas
(2024)The compositional variability of igneous rocks in arc systems is a result of several different processes concurring to magmatic differentiation. These include crystallisation-differentiation, mixing, assimilation of crustal lithologies, lower crustal anatexis, assimilation of previous cogenetic pulses or mantle-related processes, such as melting mechanisms (flux and decompression melting) or the relative contribution of the subducting ...Doctoral Thesis -
Tectonic Quakes and Meteoritic Impacts on Mars
(2024)The NASA InSight mission has placed the first seismometer on the surface of Mars. Between 2019 and 2022, it has recorded a rich set of seismic data, supplemented by wind, temperature, and pressure data. The Marsquake Service (MQS) has cataloged over 1300 seismic events in the data, some of these were identified as meteoritic impacts. The InSight seismic data contain a number of characteristic signals that must be understood to interpret ...Doctoral Thesis -
Vision for Autonomous Systems: From Tracking and Prediction to Quantum Computing
(2024)Autonomous systems strongly rely on computer vision to build a comprehensive model for understanding the environment they are embedded in. This task needs to be solved on multiple levels of abstraction, ranging from a high-level understanding of agent intentions to solving combinatorial problems for fundamental vision tasks. In this thesis, we focus on applications at three of these levels. On the most abstract level, we study the ...Doctoral Thesis -
Characterization of genomic variation and its association with complex traits and gene expression in cattle
(2024)Cattle play a pivotal role in agriculture, providing vital resources such as milk and meat, and have a special cultural significance. Domestication and human mediated selection have led to the diversification of cattle breeds worldwide. In recent decades, genomic technologies, in particular whole genome sequencing, have revolutionised our understanding of the genetic diversity within cattle populations. However, many aspects of their ...Doctoral Thesis -
The Seismicity of Mars Recorded by InSight
(2024)The InSight mission is the first Martian lander since the Viking missions in the late 1970s that has successfully deployed a seismometer in order to measure the seismicity of Mars. From early 2019 to late 2022, InSight collected a nearly-continuous high-quality seismic data set that demonstrates that Mars is seismically active. Over 1300 seismic event signals were cataloged by the Marsquake Service (MQS), which are associated both to ...Doctoral Thesis -
Take care: mineralization, hydrochemistry and the environments of greek thermalism in the nineteenth and twentieth centuries
(2024)The scientific analysis of mineral springs, rocks, and soil in Greece in the late nineteenth century led to a new understanding of the country’s landscape and resources: its airs, waters, and places. In a process of conceptual mineralization, the terrain was documented as a broad chemical network with healing properties. Doctors, chemists, and geologists constructed knowledge through fieldwork, laboratory studies, and treatises. From ...Doctoral Thesis