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Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells
(2021)bioRxivThe capacity of humoral B cell-mediated immunity to effectively respond to and protect against pathogenic infections is largely driven by the presence of a diverse repertoire of polyclonal antibodies in the serum, which are produced by plasma cells (PCs).1,2 Recent studies have started to reveal the balance between deterministic mechanisms and stochasticity of antibody repertoires on a genotypic level (i.e., clonal diversity, somatic ...Working Paper -
Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections
(2021)bioRxivCD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the duration and extent of antigen exposure. Similarly, viral infections can exert diverse selective pressures on populations of clonally related T cells. Technical limitations have nevertheless made it challenging to investigate the relationship between ...Working Paper -
A new theoretical framework jointly explains behavioral and neural variability across subjects performing flexible decision-making
(2022)bioRxivThe ability to flexibly select and accumulate relevant information to form decisions, while ignoring irrelevant information, is a fundamental component of higher cognition. Yet its neural mechanisms remain unclear. Here we demonstrate that, under assumptions supported by both monkey and rat data, the space of possible network mechanisms to implement this ability is spanned by the combination of three different components, each with specific ...Working Paper -
The Chloroflexi supergroup is metabolically diverse and representatives have novel genes for non-photosynthesis based CO2 fixation
(2021)bioRxivThe Chloroflexi superphylum have been investigated primarily from the perspective of reductive dehalogenation of toxic compounds, anaerobic photosynthesis and wastewater treatment, but remain relatively little studied compared to their close relatives within the larger Terrabacteria group, including Cyanobacteria, Actinobacteria, and Firmicutes. Here, we conducted a detailed phylogenetic analysis of the phylum Chloroflexota, the ...Working Paper -
The Robotic Herd: Using Human-Bot Interactions to Explore Irrational Herding
(2023)SocArXivWe explore human herding in a strategic setting where humans interact with automated entities (bots) and study the shift in the behavior and beliefs of humans when they are aware of interacting with bots. The strategic setting is an online minority game, where 1,997 participants are rewarded for following the minority strategy. This setting permits distinguishing between irrational herding and rational self-interesta fundamental challenge ...Working Paper -
Tracing the Footsteps of Ideas: Time-respecting Paths Reveal Key Reformers and Communication Pathways in Protestant Letter Networks
(2023)SocArXivThe transmission of ideas plays a vital role in shaping society, fostering critical thinking, driving innovation, and facilitating cultural development. Previous studies have predominantly employed aggregated networks to investigate how ideas propagate through interactions and relationships among individuals. However, these approaches overlook the temporal ordering of interactions, distorting topological network measures and potentially ...Working Paper -
Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants
(2023)bioRxivMost COVID-19 antibody therapies rely on binding the SARS-CoV-2 receptor binding domain (RBD). However, heavily mutated variants such as Omicron and its sublineages, which are characterized by an ever increasing number of mutations in the RBD, have rendered prior antibody therapies ineffective, leaving no clinically approved antibody treatments for SARS-CoV-2. Therefore, the capacity of therapeutic antibody candidates to bind and neutralize ...Working Paper -
Morphometry and mechanical instability at the onset of epithelial bladder cancer
(2023)bioRxivMalignancies of epithelial tissues, called carcinomas, account for the majority of cancer cases. Much cancer research has focused on genetic alterations and their relation to different carcinoma phenotypes. Besides a rewiring in the signalling networks, carcinoma progression is accompanied by mechanical changes in the epithelial cells and the extracellular matrix. Here, we reveal intricate morphologies in the basement membrane at the onset ...Working Paper -
Success factors of growth-stage digital health companies: protocol for a systematic literature review
(2024)medRxivBackground The healthcare industry is undergoing rapid transformation and progress, fueled by technological advances and the growing need for accessible, affordable, and high-quality healthcare services. While there has been significant progress in digitizing healthcare, especially during the COVID-19 pandemic, there is still considerable untapped potential for digital therapeutics (DTx). According to a report by Bloomberg, the digital ...Working Paper -
reComBat: Batch effect removal in large-scale, multi-source omics data integration
(2021)bioRxivWith the steadily increasing abundance of omics data produced all over the world, some-times decades apart and under vastly different experimental conditions residing in public databases, a crucial step in many data-driven bioinformatics applications is that of data integration. The challenge of batch effect removal for entire databases lies in the large number and coincide of both batches and desired, biological variation resulting in ...Working Paper