Search
Results
-
A Weighted Balance Model of Opinion Hyperpolarization
(2019)SocArXivPolarization is threatening the stability of democratic societies. Until now, polarization research has focused on opinion extremeness, overlooking the correlation between different policy issues. We explain the emergence of hyperpolarization, i.e. the combination of extremeness and correlation between issues, by developing Weighted Balance Theory (WBT), a new theory of opinion formation. WBT extends Heiders cognitive balance theory to ...Working Paper -
Cell-based simulations of Notch-dependent cell differentiation on growing domains
(2019)bioRxivNotch signalling controls cell differentiation and proliferation in many tissues. The Notch signal is generated by the interaction between the Notch receptor of one cell with the Notch ligand (Delta or Jagged) of a neighbouring cell. Therefore, the pathway requires cell-cell contact in order to be active. During organ development, cell differentiation occurs concurrently with tissue growth and changes in cell morphology. How growth impacts ...Working Paper -
Potential influence of overpressurized gas on the induced seismicity in the St. Gallen deep geothermal project (Switzerland)
(2019)Solid Earth DiscussionsIn July 2013, the city of St. Gallen conducted a deep geothermal project that aimed to exploit energy for district heating and generating power. A few days after an injection test and two acid stimulations that caused only minor seismicity, a gas kick forced the operators to inject drilling mud to combat the kick. Subsequently, multiple earthquakes were induced on a fault several hundred meters away from the well, including a ML 3.5 event ...Working Paper -
Generating customized compound libraries for drug discovery with machine intelligence
(2019)ChemRxivGenerative machine learning models sample drug-like molecules from chemical space without the need for explicit design rules. A deep learning framework for customized compound library generation is presented, aiming to enrich and expand the pharmacologically relevant chemical space with new molecular entities 'on demand'. This de novo design approach was used to generate molecules that combine features from bioactive synthetic compounds ...Working Paper -
Modelling impacts of spatially variable erosion drivers on suspended sediment dynamics
(2019)Earth Surface Dynamics DiscussionsWorking Paper -
PHYTOBASE: A global synthesis of open ocean phytoplankton occurrences
(2019)Earth System Science Data DiscussionsMarine phytoplankton are responsible for half of the global net primary production and perform multiple other ecological functions and services of the global ocean. These photosynthetic organisms comprise more than 4300 marine species, but their biogeographic patterns and the resulting species diversity are poorly known, mostly owing to severe data limitations. Here, we compile, synthesize, and harmonize marine phytoplankton occurrence ...Working Paper -
CHLSOC: The Chilean Soil Organic Carbon database, a multi-institutional collaborative effort
(2019)Earth System Science Data DiscussionsOne of the critical aspects in modelling soil organic carbon (SOC) predictions is the lack of access to soil information which is usually concentrated in regions of high agricultural interest. In Chile, most soil and SOC data to date is highly concentrated in 25 % of the territory that has intensive agricultural or forestry use. Vast areas beyond those forms of land use have few or no soil data available. Here, we present a new database ...Working Paper -
An Optimized Registration Workflow and Standard Geometric Space for Small Animal Brain Imaging
(2019)bioRxivThe reliability of scientific results critically depends on reproducible and transparent data processing. Cross-subject and cross-study comparability of imaging data in general, and magnetic resonance imaging (MRI) data in particular, is contingent on the quality of registration to a standard reference space. In small animal MRI this is not adequately provided by currently used processing workflows, which utilize high-level scripts optimized ...Working Paper -
Inconsistencies between chemistry climate model and observed lower stratospheric trends since 1998
(2019)Atmospheric Chemistry and Physics DiscussionsThe stratospheric ozone layer shields surface life from harmful ultraviolet radiation. Following the Montreal Protocol ban of long-lived ozone depleting substances (ODSs), rapid depletion of total column ozone (TCO) ceased in the late 1990s and ozone above 32 km now enjoys a clear recovery. However, there is still no confirmation of TCO recovery, and evidence has emerged that ongoing quasi-global (60° S–60° N) lower stratospheric ozone ...Working Paper