Search
Results
-
Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants
(2023)bioRxivMost COVID-19 antibody therapies rely on binding the SARS-CoV-2 receptor binding domain (RBD). However, heavily mutated variants such as Omicron and its sublineages, which are characterized by an ever increasing number of mutations in the RBD, have rendered prior antibody therapies ineffective, leaving no clinically approved antibody treatments for SARS-CoV-2. Therefore, the capacity of therapeutic antibody candidates to bind and neutralize ...Working Paper -
Database for design-compatible waveforms
(2023)Abstract on selection of ground motions for microzonation. We have analyzed and compared the stations metadata of three strong motion databases: KiK-net (Japan), ESM (Europe and Middle East), and NGA-West2 (USA). For each data-base, we propose a subset of stations suitable for the purposes of the project. These sub-sets of stations comprise 772 sites classified in terms of SIA261 (2020) soil categories (A-E), inspecting the provided VS ...Report -
The Robotic Herd: Using Human-Bot Interactions to Explore Irrational Herding
(2023)SocArXivWe explore human herding in a strategic setting where humans interact with automated entities (bots) and study the shift in the behavior and beliefs of humans when they are aware of interacting with bots. The strategic setting is an online minority game, where 1,997 participants are rewarded for following the minority strategy. This setting permits distinguishing between irrational herding and rational self-interesta fundamental challenge ...Working Paper -
Morphometry and mechanical instability at the onset of epithelial bladder cancer
(2023)bioRxivMalignancies of epithelial tissues, called carcinomas, account for the majority of cancer cases. Much cancer research has focused on genetic alterations and their relation to different carcinoma phenotypes. Besides a rewiring in the signalling networks, carcinoma progression is accompanied by mechanical changes in the epithelial cells and the extracellular matrix. Here, we reveal intricate morphologies in the basement membrane at the onset ...Working Paper -
Tracing the Footsteps of Ideas: Time-respecting Paths Reveal Key Reformers and Communication Pathways in Protestant Letter Networks
(2023)SocArXivThe transmission of ideas plays a vital role in shaping society, fostering critical thinking, driving innovation, and facilitating cultural development. Previous studies have predominantly employed aggregated networks to investigate how ideas propagate through interactions and relationships among individuals. However, these approaches overlook the temporal ordering of interactions, distorting topological network measures and potentially ...Working Paper -
A new theoretical framework jointly explains behavioral and neural variability across subjects performing flexible decision-making
(2022)bioRxivThe ability to flexibly select and accumulate relevant information to form decisions, while ignoring irrelevant information, is a fundamental component of higher cognition. Yet its neural mechanisms remain unclear. Here we demonstrate that, under assumptions supported by both monkey and rat data, the space of possible network mechanisms to implement this ability is spanned by the combination of three different components, each with specific ...Working Paper -
Modelling life cycle costs for edge beams of three Norwegian bridges
(2022)NPRA ReportsFor the planning of cost-effective infrastructure maintenance, it is important to assess the condition of structures and to estimate the optimum time, the extent and the type of repair needed to continue operating the structures safely. In this study, a novel approach is presented, which combines data from condition assessment of reinforced concrete structures (e.g. chloride profiles), predictive modelling (future chloride ingress) and ...Report -
Comment on "A literature review and meta-analysis of the effects of lockdowns on COVID-19 mortality"
(2022)In a recent working paper, Herby et al. conduct a systematic review and meta-analysis of the effects of lockdowns on COVID-19 mortality. Based on their results, they conclude that "lockdowns have had little to no public health effects'' and that "lockdowns should be rejected out of hand as a pandemic policy instrument'' (p. 2). These strong conclusions have quickly been taken up by the public media. Here, we would like to comment on the ...Working Paper -
Techno-Economic Assessment & Life Cycle Assessment Guidelines for CO2 Utilization (Version 2.0)
(2022)Climate change is one of the greatest challenges of our time. Under the auspices of the UN Framework Convention on Climate Change and through the Paris Agreement, there is a commitment to keep global temperature rise this century to well below two degrees Celsius compared with pre-industrial levels. This will require a variety of strategies, including increased renewable power generation, broad-scale electrification, greater energy ...Report -
reComBat: Batch effect removal in large-scale, multi-source omics data integration
(2021)bioRxivWith the steadily increasing abundance of omics data produced all over the world, some-times decades apart and under vastly different experimental conditions residing in public databases, a crucial step in many data-driven bioinformatics applications is that of data integration. The challenge of batch effect removal for entire databases lies in the large number and coincide of both batches and desired, biological variation resulting in ...Working Paper