Recent Submissions 

  1. Protective fibroblastic niches in secondary lymphoid organs 

    De Martin, Angelina; Stanossek, Yves; Pikor, Natalia Barbara; et al. (2023)
    Journal of Experimental Medicine
    Lymphoid organ fibroblasts, known as fibroblastic reticular cells (FRCs), generate specialized niches in the tissue and coordinate immune cell interactions. De Martin and colleagues discuss basic concepts of FRC biology and how FRCs determine activation or attenuation of immune responses.
    Review Article
  2. Modelling and simulation of metal additive manufacturing processes with particle methods: A review 

    Afrasiabi, Mohamadreza; Bambach, Markus (2023)
    Virtual and Physical Prototyping
    The critical role that numerical simulation plays in additive manufacturing has stimulated research on the effectiveness and potential applications of mesh-free, particle-based discretisation techniques. These methods excel at handling fluid flows and are viable alternatives to the mesh-based techniques typically used in commercial simulation software. In this paper, we review recent advances in developing computational models for metal ...
    Review Article
  3. Oxygen isotope ratios of phosphates in the soil-plant system: Limitations and future developments 

    von Sperber, Christian; Pistocchi, Chiara; Weiler, Markus; et al. (2023)
    European Journal of Soil Science
    The oxygen isotope ratio of phosphates is a powerful tool to study phosphorus in the soil-plant system. In the past two decades, the scientific community has made substantial progress in characterizing biogeochemical processes that lead to an alteration of oxygen isotope ratios in phosphates and in evaluating oxygen isotope ratios of phosphates in plants and soils under various environmental conditions around the globe. However, there are ...
    Review Article
  4. From microbiome composition to functional engineering, one step at a time 

    Burz, Sebastian Dan; Causevic, Senka; Dal Co, Alma; et al. (2023)
    Microbiology and Molecular Biology Reviews
    Communities of microorganisms (microbiota) are present in all habitats on Earth and are relevant for agriculture, health, and climate. Deciphering the mechanisms that determine microbiota dynamics and functioning within the context of their respective environments or hosts (the microbiomes) is crucially important. However, the sheer taxonomic, metabolic, functional, and spatial complexity of most microbiomes poses substantial challenges ...
    Review Article
  5. Advanced strategies for solid electrolyte interface design with MOF materials 

    Lu, Guolong; Meng, Ge; Liu, Qian; et al. (2024)
    Advanced Powder Materials
    Emerging energy technologies, aimed at addressing the challenges of energy scarcity and environmental pollution, have become a focal point for society. However, these actualities present significant challenges for modern energy storage devices. Lithium metal batteries (LMBs) have gained considerable attention due to their high energy density. Nonetheless, their use of liquid electrolytes raises safety concerns, including dendritic growth, ...
    Review Article
  6. Spike-based local synaptic plasticity: a survey of computational models and neuromorphic circuits 

    Khacef, Lyes; Klein, Philipp; Cartiglia, Matteo; et al. (2023)
    Neuromorphic Computing and Engineering
    Understanding how biological neural networks carry out learning using spike-based local plasticity mechanisms can lead to the development of real-time, energy-efficient, and adaptive neuromorphic processing systems. A large number of spike-based learning models have recently been proposed following different approaches. However, it is difficult to assess if these models can be easily implemented in neuromorphic hardware, and to compare ...
    Review Article
  7. Protein Engineering and High-Throughput Screening by Yeast Surface Display: Survey of Current Methods 

    Lopez-Morales, Joanan; Vanella, Rosario; Appelt, Elizabeth A.; et al. (2023)
    Small Science
    Yeast surface display (YSD) is a powerful tool in biotechnology that links genotype to phenotype. In this review, the latest advancements in protein engineering and high-throughput screening based on YSD are covered. The focus is on innovative methods for overcoming challenges in YSD in the context of biotherapeutic drug discovery and diagnostics. Topics ranging from titrating avidity in YSD using transcriptional control to the development ...
    Review Article
  8. Shaping the development and use of Artificial Intelligence: how human factors and ergonomics expertise can become more pertinent 

    Grote, Gudela (2023)
    New developments in Artificial Intelligence (AI) are extensively discussed in public media and scholarly publications. While in many academic disciplines debates on the challenges and opportunities of Artificial Intelligence (AI) and how to best address them have been launched, the human factors and ergonomics (HFE) community has been strangely quiet. I discuss three main areas in which HFE could and should significantly contribute to the ...
    Review Article
  9. Too big not to fail: emerging evidence for size-induced senescence 

    Manohar, Sandhya; Neurohr, Gabriel E. (2023)
    The FEBS Journal
    Cellular senescence refers to a permanent and stable state of cell cycle exit. This process plays an important role in many cellular functions, including tumor suppression. It was first noted that senescence is associated with increased cell size in the early 1960s; however, how this contributes to permanent cell cycle exit was poorly understood until recently. In this review, we discuss new findings that identify increased cell size as ...
    Review Article
  10. Designing molecules with autoencoder networks 

    Ilnicka, Agnieszka; Schneider, Gisbert (2023)
    Nature Computational Science
    Autoencoders are versatile tools in molecular informatics. These unsupervised neural networks serve diverse tasks such as data-driven molecular representation and constructive molecular design. This Review explores their algorithmic foundations and applications in drug discovery, highlighting the most active areas of development and the contributions autoencoder networks have made in advancing this field. We also explore the challenges ...
    Review Article
  11. Three Decades of Climate Mitigation Policy: What Has It Delivered? 

    Hoppe, Janna; Hinder, Ben; Rafaty, Ryan; et al. (2023)
    Annual Review of Environment and Resources
    After tentative efforts during the 1990s, the past two decades have seen a rapid increase in the number of greenhouse gas (GHG) emissions mitigation policies, initially in a few frontrunner countries and more recently spreading globally. Over the same period, GHG emissions have continued to rise, but the rate of growth has recently slowed. Are mitigation policies having an effect? To explore this question, we review and synthesize the ...
    Review Article
  12. Unleashing the Potential of MXene-Based Flexible Materials for High-Performance Energy Storage Devices 

    Zhou, Yunlei; Yin, Liting; Xiang, Shuangfei; et al. (2023)
    Advanced Science
    Since the initial discovery of Ti3C2 a decade ago, there has been a significant surge of interest in 2D MXenes and MXene-based composites. This can be attributed to the remarkable intrinsic properties exhibited by MXenes, including metallic conductivity, abundant functional groups, unique layered microstructure, and the ability to control interlayer spacing. These properties contribute to the exceptional electrical and mechanical performance ...
    Review Article
  13. Effectiveness of holistic mobile health interventions on diet, and physical, and mental health outcomes: a systematic review and meta-analysis 

    Zheng, Shenglin; Edney, Sarah Martine; Goh, Chin Hao; et al. (2023)
    Background: Good physical and mental health are essential for healthy ageing. Holistic mobile health (mHealth) interventions—including at least three components: physical activity, diet, and mental health—could support both physical and mental health and be scaled to the population level. This review aims to describe the characteristics of holistic mHealth interventions and their effects on related behavioural and health outcomes among ...
    Review Article
  14. Cloud manufacturing for industrialized construction: Opportunities and challenges for a new manufacturing model 

    Custovic, Irfan; Cao, Jianpeng; Hall, Daniel (2023)
    Journal of Infrastructure Intelligence and Resilience
    More widespread use of industrialized construction (IC) is hampered by the high capital cost of advanced production facilities paired with low profit margins. A novel service-oriented cloud manufacturing (CMfg) model could in theory increase utilization and profitability of distributed production facilities. However, little research has investigated how IC can benefit from the CMfg model. This paper examines opportunities and challenges ...
    Review Article
  15. Do robots outperform humans in human-centered domains? 

    Riener, Robert; Rabezzana, Luca; Zimmermann, Yves (2023)
    Frontiers in Robotics and AI
    The incessant progress of robotic technology and rationalization of human manpower induces high expectations in society, but also resentment and even fear. In this paper, we present a quantitative normalized comparison of performance, to shine a light onto the pressing question, “How close is the current state of humanoid robotics to outperforming humans in their typical functions (e.g., locomotion, manipulation), and their underlying ...
    Review Article
  16. High Aspect Ratio Nanoscale Pores through BCP-Based Metal Oxide Masks and Advanced Dry Etching 

    Paiva, Aislan Esmeraldo; Gerlt, Michael S.; Läubli, Nino; et al. (2023)
    ACS Applied Materials & Interfaces
    The reliable and regular modification of the surface properties of substrates plays a crucial role in material research and the development of functional surfaces. A key aspect of this is the development of the surface pores and topographies. These can confer specific advantages such as high surface area as well as specific functions such as hydrophobic properties. Here, we introduce a combination of nanoscale self-assembled block-copolymer-based ...
    Review Article
  17. As a matter of fat: Emerging roles of lipid-sensitive E3 ubiquitin ligases 

    Gawden-Bone, Christian M.; Lehner, Paul J.; Volkmar, Norbert (2023)
    The dynamic structure and composition of lipid membranes need to be tightly regulated to control the vast array of cellular processes from cell and organelle morphology to protein-protein interactions and signal transduction pathways. To maintain membrane integrity, sense-and-response systems monitor and adjust membrane lipid composition to the ever-changing cellular environment, but only a relatively small number of control systems have ...
    Review Article
  18. Algal blooms in the ocean: hot spots for chemically mediated microbial interactions 

    Kuhlisch, Constanze; Shemi, Adva; Barak-Gavish, Noa; et al. (2023)
    Nature Reviews Microbiology
    The cycling of major nutrients in the ocean is affected by large-scale phytoplankton blooms, which are hot spots of microbial life. Diverse microbial interactions regulate bloom dynamics. At the single-cell level, interactions between microorganisms are mediated by small molecules in the chemical crosstalk that determines the type of interaction, ranging from mutualism to pathogenicity. Algae interact with viruses, bacteria, parasites, ...
    Review Article
  19. Mechanical forces and the 3D genome 

    Shivashankar, G.V. (2023)
    Current Opinion in Structural Biology
    Traditionally, the field of genomics has been studied from a biochemical perspective. Besides chemical influences, cells are subject to a variety of mechanical signals from their surrounding tissue microenvironment. These mechanical signals can not only cause changes to a cell's physical structure but can also lead to alterations in their genomes and gene expression programs. Understanding the mechanical control of genome organization and ...
    Review Article
  20. A global systematic overview of socioeconomic factors associated with antidiabetic medication adherence in individuals with type 2 diabetes 

    Studer, Christian Ming; Linder, Marie; Pazzagli, Laura (2023)
    Journal of Health, Population and Nutrition
    Background: Antidiabetic medication adherence is a key aspect for successful control of type 2 diabetes mellitus (T2DM). This systematic review aims to provide an overview of the associations between socioeconomic factors and antidiabetic medication adherence in individuals with T2DM. Methods: A study protocol was established using the PRISMA checklist. A primary literature search was conducted during March 2022, searching PubMed, Embase, ...
    Review Article

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