Liver-tumor model based on spheroids in microfluidic networks for pharmacokinetic studies
dc.contributor.author
Kim, Jin-Young
dc.contributor.author
Fluri, David
dc.contributor.author
Kelm, Jens M.
dc.contributor.author
Hierlemann, Andreas
dc.contributor.author
Frey, Olivier
dc.date.accessioned
2020-02-21T12:06:58Z
dc.date.available
2017-06-11T15:46:38Z
dc.date.available
2018-10-11T08:43:31Z
dc.date.available
2020-02-21T12:06:58Z
dc.date.issued
2014
dc.identifier.isbn
978-0-9798064-7-6
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/97153
dc.description.abstract
A simple in vitro model for physiological organ-to-organ interaction studies was realized by using spherical microtissues (MTs) cultured in a microfluidic network. We used primary rat liver (rLi) MTs as liver model and human colon carcinoma (HCT116) MTs as tumor model that were cultured in dedicated microchambers and that were fluidically connected with a microchannel. Medium was internally circulated by using gravity-driven flow. The in vitro model was validated by comparing the bioactivation of an anticancer pro-drug, cyclophosphamide (CPA), under perfusion conditions and under conventional static conditions.
en_US
dc.language.iso
en
en_US
dc.publisher
Chemical and Biological Microsystems Society
en_US
dc.subject
3D cell culture
en_US
dc.subject
Microtissues
en_US
dc.subject
Spheroids
en_US
dc.subject
Microfluidics
en_US
dc.subject
Gravity-driven flow
en_US
dc.title
Liver-tumor model based on spheroids in microfluidic networks for pharmacokinetic studies
en_US
dc.type
Other Conference Item
ethz.book.title
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
ethz.pages.start
754
en_US
ethz.pages.end
756
en_US
ethz.event
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2014)
en_US
ethz.event.location
San Antonio, TX, USA
en_US
ethz.event.date
October 26-30, 2014
en_US
ethz.notes
Poster abstract. Poster presentation on October 29, 2014.
en_US
ethz.grant
The Body-on-a-Chip (BoC)
en_US
ethz.grant
The Body on a Chip - Human 3-D tissue analogues in microfluidic systems
en_US
ethz.publication.place
San Diego, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
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296257
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142440
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296257
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142440
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296257
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142440
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EC
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SNF
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EC
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SNF
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EC
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SNF
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100000780
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
FP7
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Ambizione
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FP7
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Ambizione
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FP7
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Ambizione
ethz.date.deposited
2017-06-11T15:46:48Z
ethz.source
ECIT
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imp593652dcce91a61238
ethz.ecitpid
pub:152060
ethz.eth
yes
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ethz.availability
Metadata only
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ethz.rosetta.installDate
2018-10-11T08:43:34Z
ethz.rosetta.lastUpdated
2022-03-29T01:03:23Z
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