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p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment
(2011)Molecular Biology of the CellThe spindle assembly checkpoint links the onset of anaphase to completion of chromosome-microtubule attachment and is mediated by the binding of Mad and Bub proteins to kinetochores of unattached or maloriented chromosomes. Mad2 and BubR1 traffic between kinetochores and the cytosol, thereby transmitting a “wait anaphase” signal to the anaphase-promoting complex. It is generally assumed that this signal dissipates automatically upon ...Journal Article -
Intrinsic noise alters the frequency spectrum of mesoscopic oscillatory chemical reaction systems
(2011)Scientific ReportsMesoscopic oscillatory reaction systems, for example in cell biology, can exhibit stochastic oscillations in the form of cyclic random walks even if the corresponding macroscopic system does not oscillate. We study how the intrinsic noise from molecular discreteness influences the frequency spectrum of mesoscopic oscillators using as a model system a cascade of coupled Brusselators away from the Hopf bifurcation. The results show that the ...Journal Article -
Cryoelectron tomography of radial spokes in cilia and flagella
(2011)The Journal of Cell BiologyRadial spokes (RSs) are ubiquitous components in the 9 + 2 axoneme thought to be mechanochemical transducers involved in local control of dynein-driven microtubule sliding. They are composed of >23 polypeptides, whose interactions and placement must be deciphered to understand RS function. In this paper, we show the detailed three-dimensional (3D) structure of RS in situ in Chlamydomonas reinhardtii flagella and Tetrahymena thermophila ...Journal Article -
Determination of Jet Energy Calibration and Transverse Momentum Resolution in CMS
(2011)Journal of InstrumentationMeasurements of the jet energy calibration and transverse momentum resolution in CMS are presented, performed with a data sample collected in proton-proton collisions at a centre-of-mass energy of 7TeV, corresponding to an integrated luminosity of 36pb−1. The transverse momentum balance in dijet and γ/Z+jets events is used to measure the jet energy response in the CMS detector, as well as the transverse momentum resolution. The results ...Journal Article -
Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice
(2011)Molecular Biology of the CellEnd-binding proteins (EBs) comprise a conserved family of microtubule plus end–tracking proteins. The concerted action of calponin homology (CH), linker, and C-terminal domains of EBs is important for their autonomous microtubule tip tracking, regulation of microtubule dynamics, and recruitment of numerous partners to microtubule ends. Here we report the detailed structural and biochemical analysis of mammalian EBs. Small-angle X-ray ...Journal Article -
Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields
(2011)British Journal of CancerBackground: Therapeutic options for patients with advanced hepatocellular carcinoma (HCC) are limited. There is emerging evidence that the growth of cancer cells may be altered by very low levels of electromagnetic fields modulated at specific frequencies. Methods: A single-group, open-label, phase I/II study was performed to assess the safety and effectiveness of the intrabuccal administration of very low levels of electromagnetic ...Journal Article -
Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture
(2011)The EMBO JournalJournal Article -
Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress
(2011)The EMBO JournalJournal Article -
Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
(2011)Journal of Experimental MedicineThe HIV-1 envelope trimer adopts a quaternary conformation that effectively shields neutralization-sensitive domains and thus represents a major obstacle for natural and vaccine-elicited antibody responses. By using a structure–function analysis based on a specifically devised mathematical model, we demonstrate in this study that protection from neutralization is enforced by intersubunit contact between the variable loops 1 and 2 (V1V2) ...Journal Article -
Moving Universities: A Case Study on the Use of Unconferencing for Facilitating Sustainability Learning in a Swiss University
(2011)SustainabilityUnconferencing is a method for organizing social learning which could be suitable to trigger sustainability learning processes. An unconference is defined as participant-driven meeting that tries to avoid one or more aspects of a conventional conference, such as top-down organization, one-way communication and power-relationships based on titles, formal hierarchies and status. This paper presents a case study on the application of ...Journal Article