Search
Results
-
Inkjet Printing of High Aspect Ratio Superparamagnetic SU-8 Microstructures with Preferential Magnetic Directions
(2014)MicromachinesStructuring SU-8 based superparamagnetic polymer composite (SPMPC) containing Fe3O4 nanoparticles by photolithography is limited in thickness due to light absorption by the nanoparticles. Hence, obtaining thicker structures requires alternative processing techniques. This paper presents a method based on inkjet printing and thermal curing for the fabrication of much thicker hemispherical microstructures of SPMPC. The microstructures are ...Journal Article -
An Academic Response to Basel 3.5
(2014)RisksRecent crises in the financial industry have shown weaknesses in the modeling of Risk-Weighted Assets (RWAs). Relatively minor model changes may lead to substantial changes in the RWA numbers. Similar problems are encountered in the Value-at-Risk (VaR)-aggregation of risks. In this article, we highlight some of the underlying issues, both methodologically, as well as through examples. In particular, we frame this discussion in the context ...Journal Article -
Recommendations for Standardizing Validation Procedures Assessing Physical Activity of Older Persons by Monitoring Body Postures and Movements
(2014)SensorsPhysical activity is an important determinant of health and well-being in older persons and contributes to their social participation and quality of life. Hence, assessment tools are needed to study this physical activity in free-living conditions. Wearable motion sensing technology is used to assess physical activity. However, there is a lack of harmonisation of validation protocols and applied statistics, which make it hard to compare ...Journal Article -
Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction
(2014)Molecular Therapy - Nucleic AcidsGene knockdown using micro RNA (miRNA)-based vector constructs is likely to become a prominent gene therapy approach. It was the aim of this study to improve the efficiency of gene knockdown through optimizing the structure of miRNA mimics. Knockdown of two target genes was analyzed: CCR5 and green fluorescent protein. We describe here a novel and optimized miRNA mimic design called mirGE comprising a lower stem length of 13 base pairs ...Journal Article -
A way forward for Cosmic Shear: Monte-Carlo Control Loops
(2014)Physics of the Dark UniverseWeak lensing by large scale structure or ‘cosmic shear’ is a potentially powerful cosmological probe to shed new light on Dark Matter, Dark Energy and Modified Gravity. It is based on the weak distortions induced by large-scale structures on the observed shapes of distant galaxies through gravitational lensing. While the potentials of this purely gravitational effect are great, results from this technique have been hampered because the ...Journal Article -
Antihyperalgesia by α2-GABAA Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites
(2014)NeuropsychopharmacologyJournal Article -
Developing a GIS-Based Visual-Acoustic 3D Simulation for Wind Farm Assessment
(2014)ISPRS International Journal of Geo-InformationPublic landscape impact assessment of renewable energy installations is crucial for their acceptance. Thus, a sound assessment basis is crucial in the implementation process. For valuing landscape perception, the visual sense is the dominant human sensory component. However, the visual sense provides only partial information about our environment. Especially when it comes to wind farm assessments, noise produced by the rotating turbine ...Journal Article -
The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection
(2013)mBioThe intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining homeostasis. Listeria monocytogenes is the agent of listeriosis, an infection transmitted to humans upon ingestion of contaminated food. Crossing of the intestinal barrier is a critical step of the infection before dissemination ...Journal Article -
SATB1 collaborates with loss of p16 in cellular transformation
(2013)OncogeneTumor progression is associated with invasiveness and metastatic potential. The special AT-rich binding protein 1 (SATB1) has been identified as a key factor in the progression of breast cancer cells to a malignant phenotype and is associated with progression of human tumors. In normal development, SATB1 coordinates gene expression of progenitor cells by functioning as a genome organizer. In contrast to progenitor and tumor cells, SATB1 ...Journal Article -
Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage
(2013)Cell Death and DifferentiationJournal Article