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Epigenetics and proteomics join transcriptomics in the quest for tuberculosis biomarkers
(2015)mBioAn estimated one-third of the world's population is currently latently infected with Mycobacterium tuberculosis. Latent M. tuberculosis infection (LTBI) progresses into active tuberculosis (TB) disease in ~5 to 10% of infected individuals. Diagnostic and prognostic biomarkers to monitor disease progression are urgently needed to ensure better care for TB patients and to decrease the spread of TB. Biomarker development is primarily based ...Journal Article -
Observation of the rare Bs0 →µ+µ− decay from the combined analysis of CMS and LHCb data
(2015)NatureThe standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilities, or branching fractions, of the strange B meson ( ) and the B0 meson decaying into two oppositely charged muons (μ+ and μ−) are especially interesting because of their sensitivity to ...Journal Article -
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease
(2014)Nature BiotechnologyThe domestic ferret (Mustela putorius furo) is an important animal model for multiple human respiratory diseases. It is considered the 'gold standard' for modeling human influenza virus infection and transmission. Here we describe the 2.41 Gb draft genome assembly of the domestic ferret, constituting 2.28 Gb of sequence plus gaps. We annotated 19,910 protein-coding genes on this assembly using RNA-seq data from 21 ferret tissues. We ...Journal Article -
Correlations of three-dimensional motion of chromosomal loci in yeast revealed by the double-helix point spread function microscope
(2014)Molecular Biology of the CellSingle-particle tracking has been applied to study chromatin motion in live cells, revealing a wealth of dynamical behavior of the genomic material once believed to be relatively static throughout most of the cell cycle. Here we used the dual-color three-dimensional (3D) double-helix point spread function microscope to study the correlations of movement between two fluorescently labeled gene loci on either the same or different budding ...Journal Article -
An agent-based model for mRNA export through the nuclear pore complex
(2014)Molecular Biology of the CellmRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood. The density of export receptors that must bind an mRNA to ensure export, as well as how receptor distribution affects transport dynamics, is not known. It is also unclear whether the rate-limiting step for transport occurs at the nuclear basket, in the central channel, ...Journal Article -
Helsingør Statement on poly- and perfluorinated alkyl substances (PFASs)
(2014)ChemosphereIn this discussion paper, the transition from long-chain poly- and perfluorinated alkyl substances (PFASs) to fluorinated alternatives is addressed. Long-chain PFASs include perfluoroalkyl carboxylic acids (PFCAs) with 7 or more perfluorinated carbons, perfluoroalkyl sulfonic acids (PFSAs) with 6 or more perfluorinated carbons, and their precursors. Because long-chain PFASs have been found to be persistent, bioaccumulative and toxic, they ...Journal Article -
21st century climate change in the European Alps-A review
(2014)Science of The Total EnvironmentReliable estimates of future climate change in the Alps are relevant for large parts of the European society. At the same time, the complex Alpine region poses considerable challenges to climate models, which translate to uncertainties in the climate projections. Against this background, the present study reviews the state-of-knowledge about 21st century climate change in the Alps based on existing literature and additional analyses. In ...Journal Article -
Sources and distributions of branched and isoprenoid tetraether lipids on the Amazon shelf and fan
(2014)Geochimica et Cosmochimica ActaBranched glycerol dialkyl glycerol tetraethers (brGDGTs) in river fan sediments have been used successfully to reconstruct mean annual air temperature (MAAT) and soil pH of the Congo River drainage basin. However, in a previous study of Amazon deep-sea fan sediments the reconstructed MAATs were ca. 10 °C colder than the actual MAAT of the Amazon basin. In this study we investigated this apparent offset, by comparing the concentrations and ...Journal Article -
Evidence for the direct decay of the 125 GeV Higgs boson to fermions
(2014)Nature PhysicsThe discovery of a new boson with a mass of approximately 125 GeV in 2012 at the Large Hadron Collider1,2,3 has heralded a new era in understanding the nature of electroweak symmetry breaking and possibly completing the standard model of particle physics4,5,6,7,8,9. Since the first observation in decays to γγ, WW and ZZ boson pairs, an extensive set of measurements of the mass10,11 and couplings to W and Z bosons11,12,13, as well as ...Journal Article -
Dynamic Feedforward Control of a Diesel Engine Based on Optimal Transient Compensation Maps
(2014)EnergiesTo satisfy the increasingly stringent emission regulations and a demand for an ever lower fuel consumption, diesel engines have become complex systems with many interacting actuators. As a consequence, these requirements are pushing control and calibration to their limits. The calibration procedure nowadays is still based mainly on engineering experience, which results in a highly iterative process to derive a complete engine calibration. ...Journal Article