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Crack-healing, a Novel Approach for a Laser-based Powder Bed Fusion of High-performance Ceramic Oxides
(2021)Additive Manufacturing LettersLaser-based powder bed fusion (PBF-LB) of ceramic materials have not been developed sufficiently. The process-induced crack formation is the key challenge of the associated additive manufacturing method, which prevents its successful industrial implementation. Therefore, we have adopted a strategy to accept crack formation as an inherent characteristic of the manufacturing process while enhancing the mechanical properties of the parts by ...Journal Article -
Extrahypothalamic GABAergic nociceptin-expressing neurons regulate AgRP neuron activity to control feeding behavior
(2020)The Journal of Clinical InvestigationArcuate nucleus agouti–related peptide (AgRP) neurons play a central role in feeding and are under complex regulation by both homeostatic hormonal and nutrient signals and hypothalamic neuronal pathways. Feeding may also be influenced by environmental cues, sensory inputs, and other behaviors, implying the involvement of higher brain regions. However, whether such pathways modulate feeding through direct synaptic control of AgRP neuron ...Journal Article -
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
(2020)Proceedings of the National Academy of Sciences of the United States of AmericaDe novo protein design has succeeded in generating a large variety of globular proteins, but the construction of protein scaffolds with cavities that could accommodate large signaling molecules, cofactors, and substrates remains an outstanding challenge. The long, often flexible loops that form such cavities in many natural proteins are difficult to precisely program and thus challenging for computational protein design. Here we describe ...Journal Article -
Improving water ecosystem sustainability of urban water system by management strategies optimization
(2020)Journal of Environmental ManagementJournal Article -
The Study of Leaders in Nuclear Proliferation and How to Reinvigorate It
(2020)International Studies ReviewFor both nuclear proliferation and nuclear weapons restraint, the individual characteristics of political leaders—their beliefs, experiences, and identities—frequently play an important role. And yet, theories of proliferation have so far paid insufficient attention to the influence of leaders, focusing instead on international and domestic structures that allegedly determine states’ nuclear choices. This article makes two contributions. ...Journal Article