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dc.contributor.author
Hausrat, Torben J.
dc.contributor.author
Muhia, Mary
dc.contributor.author
Gerrow, Kimberly
dc.contributor.author
Thomas, Philip
dc.contributor.author
Hirdes, Wiebke
dc.contributor.author
Tsukita, Sachiko
dc.contributor.author
Heisler, Frank F.
dc.contributor.author
Herich, Lena
dc.contributor.author
Dubroqua, Sylvain
dc.contributor.author
Breiden, Petra
dc.contributor.author
Feldon, Joram
dc.contributor.author
Schwarz, Jürgen R.
dc.contributor.author
Yee, Benjamin K.
dc.contributor.author
Smart, Trevor G.
dc.contributor.author
Triller, Antoine
dc.contributor.author
Kneussel, Matthias
dc.date.accessioned
2018-09-07T16:45:40Z
dc.date.available
2017-06-11T17:28:41Z
dc.date.available
2018-09-07T16:45:40Z
dc.date.issued
2015
dc.identifier.other
10.1038/ncomms7872
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/100979
dc.identifier.doi
10.3929/ethz-b-000100979
dc.description.abstract
Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addition, lateral diffusion and confinement exchanges surface membrane receptors between synaptic and extrasynaptic sites. However, the signals that regulate this transition are currently unknown. GABAA receptors containing α5-subunits (GABAAR-α5) concentrate extrasynaptically through radixin (Rdx)-mediated anchorage at the actin cytoskeleton. Here we report a novel mechanism that regulates adjustable plasma membrane receptor pools in the control of synaptic receptor density. RhoA/ROCK signalling regulates an activity-dependent Rdx phosphorylation switch that uncouples GABAAR-α5 from its extrasynaptic anchor, thereby enriching synaptic receptor numbers. Thus, the unphosphorylated form of Rdx alters mIPSCs. Rdx gene knockout impairs reversal learning and short-term memory, and Rdx phosphorylation in wild-type mice exhibits experience-dependent changes when exposed to novel environments. Our data suggest an additional mode of synaptic plasticity, in which extrasynaptic receptor reservoirs supply synaptic GABAARs.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publishing Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Radixin regulates synaptic GABA(A) receptor density and is essential for reversal learning and short-term memory
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2015-04-20
ethz.journal.title
Nature Communications
ethz.journal.volume
6
en_US
ethz.pages.start
6872
en_US
ethz.size
17 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
007044158
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T17:28:48Z
ethz.source
ECIT
ethz.identifier.importid
imp5936532e9c1ad29984
ethz.ecitpid
pub:158628
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-14T16:59:22Z
ethz.rosetta.lastUpdated
2019-02-03T07:49:06Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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