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dc.contributor.author
Jaspers, Ellen
dc.contributor.author
Byblow, Winston D.
dc.contributor.author
Feys, Hilde
dc.contributor.author
Wenderoth, Nicole
dc.date.accessioned
2019-07-10T08:05:35Z
dc.date.available
2017-06-12T07:40:11Z
dc.date.available
2019-07-10T08:05:35Z
dc.date.issued
2016-01
dc.identifier.issn
2296-2360
dc.identifier.other
10.3389/fped.2015.00112
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/117471
dc.identifier.doi
10.3929/ethz-b-000117471
dc.description.abstract
Children with unilateral cerebral palsy (CP) typically present with largely divergent upper limb sensorimotor deficits and individual differences in response to upper limb rehabilitation. This review summarizes how early brain damage can cause dramatic deviations from the normal anatomy of sensory and motor tracts, resulting in unique “wiring patterns” of the sensorimotor system in CP. Based on the existing literature, we suggest that corticospinal tract (CST) anatomy and integrity constrains sensorimotor function of the upper limb and potentially also the response to treatment. However, it is not possible to infer CST (re)organization from clinical presentation alone and conventional biomarkers, such as time of insult, location, and lesion extent seem to have limited clinical utility. Here, we propose a theoretical framework based on a detailed examination of the motor system using behavioral, neurophysiological, and magnetic resonance imaging measures, akin to those used to predict potential for upper limb recovery of adults after stroke. This theoretical framework might prove useful because it provides testable hypotheses for future research with the goal to develop and validate a clinical assessment flowchart to categorize children with unilateral CP.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Media
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Cerebral palsy
en_US
dc.subject
Upper limb
en_US
dc.subject
Corticospinal tract
en_US
dc.subject
Reorganization
en_US
dc.subject
Biomarker
en_US
dc.subject
Categorization
en_US
dc.title
The corticospinal tract: A biomarker to categorize upper limb functional potential in unilateral cerebral palsy
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2016-01-06
ethz.journal.title
Frontiers in Pediatrics
ethz.journal.volume
3
en_US
ethz.pages.start
112
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
ethz.date.deposited
2017-06-12T07:43:28Z
ethz.source
ECIT
ethz.identifier.importid
imp59365479b3e5789941
ethz.ecitpid
pub:179378
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T08:39:28Z
ethz.rosetta.lastUpdated
2019-07-10T08:05:46Z
ethz.rosetta.versionExported
true
ethz.COinS
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