Open access
Date
2017-01Type
- Journal Article
Abstract
Formylglycine-generating enzyme (FGE) is an O2-utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that CuI is an integral cofactor of this enzyme and binds with high affinity (KD=of 10−17 m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000194066Publication status
publishedExternal links
Journal / series
ChemBioChemVolume
Pages / Article No.
Publisher
Wiley-VCHSubject
Copper; EPR; Formylglycine; Oxidases; Oxygen activation; Protein engineeringOrganisational unit
03810 - Jeschke, Gunnar / Jeschke, Gunnar
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