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A framework for efficient isogeometric computations of phase-field brittle fracture in multipatch shell structures
(2020)Computer Methods in Applied Mechanics and EngineeringWe present a computational framework for applying the phase-field approach to brittle fracture efficiently to complex shell structures. The momentum and phase-field equations are solved in a staggered scheme using isogeometric Kirchhoff–Love shell analysis for the structural part and isogeometric second- and fourth-order phase-field formulations for the brittle fracture part. For the application to complex multipatch structures, we propose ...Journal Article -
Robustness analysis of a green chemistry-based model for the classification of silver nanoparticles synthesis processes
(2017)Journal of Cleaner ProductionThis paper proposes a robustness analysis based on Multiple Criteria Decision Aiding (MCDA). The ensuing model was used to assess the implementation of green chemistry principles in the synthesis of silver nanoparticles. Its recommendations were also compared to an earlier developed model for the same purpose to investigate concordance between the models and potential decision support synergies. A three-phase procedure was adopted to ...Journal Article -
Data set for paper "Interplay of community dynamics, temperature, and productivity on the hydrogen isotope signatures of lipid biomarkers"
(2017)The hydrogen isotopic composition (δ2H) of lipid biomarkers has diverse applications in the fields of paleoclimatology, biogeochemistry, and microbial community dynamics. Large changes in hydrogen isotope fractionation have been observed among microbes with differing core metabolisms, while environmental factors including temperature and nutrient availability can affect isotope fractionation by photoautotrophs. Much effort has gone into ...Dataset -
Fe(II) interaction with cement phases: Method development, wet chemical studies and X-ray absorption spectroscopy
(2021)Journal of Colloid and Interface ScienceFe(II) interaction with cement phases was studied by means of co-precipitation and sorption experiments in combination with X-ray absorption fine structure (XAFS) spectroscopy. Oxidation of Fe(II) was fast in alkaline conditions and therefore, a methodology was developed which allowed Fe(II) to be stabilised in the sorption experiments and to prepare samples for spectroscopy. X-ray diffraction (XRD) of the co-precipitation samples showed ...Journal Article -
Design and Application of Mini‐libraries of the miRNA Probes for an Efficient and Versatile miRNA‐mRNA Cross‐linking
(2021)Chemistry - A European JournalMicroRNAs constitute a class of endogenous, non-coding RNAs that influence various processes within the cell. By base-pairing to partially-complementary sites located in the 3’ untranslated region of target messenger RNAs, microRNAs participate in post-transcriptional regulation of the majority of human protein-coding genes. Their dysregulation has been related to many pathological processes and diseases. Thus, an in-depth understanding ...Journal Article -
L1 cell adhesion molecule confers radioresistance to ovarian cancer and defines a new cancer stem cell population
(2020)CancersMany solid tumors, including ovarian cancer, contain small populations of cancer stem cells (CSCs). These cells are usually resistant against conventional cancer therapies and play a role in disease recurrence. We demonstrated that the L1 cell adhesion molecule (L1CAM) is a new CSC target in ovarian cancer, triggering radioresistance. Using fluorescence-activated cell sorting, specific cell populations expressing L1CAM alone or in combination ...Journal Article -
An overview of worldwide and regional time trends in total mercury levels in human blood and breast milk from 1966 to 2015 and their associations with health effects
(2019)Environment InternationalBackground Mercury is a pollutant of global concern. To protect human health and environment from mercury pollution, the Minamata Convention on mercury entered into force in 2017. Objectives To support a future effectiveness evaluation of the convention, this study assesses worldwide and regional time trends of total mercury levels in human blood and breast milk across different population sub-groups in the last half-century prior ...Review Article -
Effects of N-glycosylation of the human cation channel TRPA1 on agonist-sensitivity
(2016)Bioscience ReportsDetermining the functional significance of post-translational modifications advances our understanding of many broadly-expressed proteins, and particularly ion channels. The enzymes that catalyse these modifications are often expressed in a cell-type specific manner, resulting in considerable structural diversity among post-translationally modified proteins that are expressed across a variety of cell types. TRP channels exhibit notably ...Journal Article -
Modelling economic losses of historic and present-day high-impact winter windstorms in Switzerland
(2016)Tellus A: Dynamic Meteorology and OceanographyJournal Article -