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Datum
2008-02Typ
- Journal Article
ETH Bibliographie
yes
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Abstract
Calcineurin (PP2B) is a Ca2+-dependent protein phosphatase enriched in the brain that takes part in intracellular signaling pathways regulating synaptic plasticity and complex brain functions. We report here that when these pathways are activated by transgenic expression of calcineurin, locomotor activity of mice in response to novelty is increased, as well as the behavioral and molecular responses of the psychostimulant cocaine. We also observed that the anxious-like behavior is altered. These behavioral changes are indicative of a generally increased behavioral responsiveness and could be normalized by chronic treatment with the mood stabilizer valproate. These results provide proof of concept that calcineurin-dependent dephosphorylation plays an important role in behavioral reactivity and in the effects of mood regulators. Mice overexpressing calcineurin represent a novel tool to study affective responses related to psychiatric disorders. Mehr anzeigen
Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
European Journal of PharmacologyBand
Seiten / Artikelnummer
Verlag
ElsevierThema
Calcineurin; Cocaine; Valproate; Behavioral reactivity; Affective disorders; Mood stabilizerOrganisationseinheit
03518 - Mansuy, Isabelle / Mansuy, Isabelle
ETH Bibliographie
yes
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