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Population-level neural correlates of flexible avoidance learning in medial prefrontal cortex
(2023)bioRxivThe medial prefrontal cortex (mPFC) has been proposed to link sensory inputs and behavioral outputs to mediate the execution of learned behaviors. However, how such a link is implemented has remained unclear. To measure prefrontal neural correlates of sensory stimuli and learned behaviors, we performed population calcium imaging during a novel tone-signaled active avoidance paradigm in mice. We developed a novel analysis approach based ...Working Paper -
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Firm Heterogeneity, Industry Dynamics and Climate Policy
(2023)Economics Working Paper SeriesWe develop a dynamic general equilibrium model to quantify the interaction between climate policy, industry dynamics, and the elasticity of substitution between clean and dirty energy in the economy. The model incorporates empirical observations that firms differ substantially in their potential for energy substitution and that the economy is growing more capable of substituting clean for dirty energy over time as environmental regulation ...Working Paper -
How Regulation Might Fail to Reduce Energy Consumption While Still Stimulating Total Factor Productivity Growth
(2023)Economics Working Paper SeriesThis paper evaluates the impact of a policy that was implemented to reduce the energy intensity of firms in some manufacturing sectors in India, on the total factor productivity (TFP) growth of firms and on its components, scale efficiency and technical change. Using plant-level panel data on the cement industry from 2007-2015 and a difference-in-difference methodology, we find that treated plants had higher rates of TFP growth, compared ...Working Paper -
Fault Zone Spatial Stress Variations Revealed by Breakout Observations Within an Array of Boreholes Penetrating a Granitic Rock Mass
(2023)The in situ stress state within fault zones is technically challenging to characterize. At the Bedretto Underground Laboratory in the Swiss Alps, the breakouts observed in an array of eight inclined boreholes penetrating a fault zone offer a unique opportunity to characterize the fault-associated spatial stress variations. Synthesizing multiple geophysical logs, natural geological structures intersecting these boreholes are identified, ...Working Paper -
The Labor Market Effects of Restricting Refugees’ Employment Opportunities
(2023)KOF Working PapersRefugees, and immigrants more generally, often do not have access to all jobs in the labor market. We argue that restrictions on employment opportunities help explain why immigrants have lower employment and wages than native citizens. To test this hypothesis, we leverage refugees’ exogenous geographic assignment in Switzerland, within-canton variation in labor market restrictions, and linked register data 1999–2016. We document large ...Working Paper -
Introduction to Machine Learning for Physicians: A Survival Guide for Data Deluge
(2022)Many modern research fields increasingly rely on collecting and analysing massive, often unstructured, and unwieldy datasets. Consequently, there is growing interest in machine learning and artificial intelligence applications that can harness this `data deluge'. This broad nontechnical overview provides a gentle introduction to machine learning with a specific focus on medical and biological applications. We explain the common types of ...Working Paper -
Multi-location trials and population-based genotyping reveal high diversity and adaptation to breeding environments in a large collection of red clover
(2022)bioRxivRed clover (Trifolium pratense L.) is an outcrossing forage legume that has adapted to a wide range of climatic and growing conditions across Europe. Red clover is valued for its high yield potential and forage quality. The high amount of genetic diversity present in red clover provides an invaluable, but often poorly characterized resource to improve key traits such as yield, quality, and resistance to biotic and abiotic stresses. In ...Working Paper -
The protooncogene Ski regulates the neuron-glia switch during development of the mammalian cerebral cortex
(2022)bioRxivThe brain is the most complex organ in mammals and understanding the origin of this complexity is a major challenge for developmental biologists. Crucial to the size and morphology of the cortex is the timing and transition of neural stem cell (NSC) fate. An interesting candidate for modulating and fine tuning these processes is the transcriptional regulator Ski, a protooncogene expressed in cortical cells. Ski is involved in diverse ...Working Paper -
On (the Lack of) Code Confidentiality in Trusted Execution Environments
(2022)arXivTrusted Execution Environments (TEEs) have been proposed as a solution to protect code confidentiality in scenarios where computation is outsourced to an untrusted operator. We study the resilience of such solutions to side-channel attacks in two commonly deployed scenarios: when a confidential code is a native binary that is shipped and executed within a TEE and when the confidential code is an intermediate representation (IR) executed ...Working Paper