A microfluidic tilting platform for in vivo-like drug exposure of three-dimensional microtissues
dc.contributor.author
Lohasz, Christian
dc.contributor.author
Frey, Olivier
dc.contributor.author
Renggli, Kasper
dc.contributor.author
Hierlemann, Andreas
dc.date.accessioned
2020-02-20T09:35:35Z
dc.date.available
2018-01-30T16:10:33Z
dc.date.available
2018-01-31T06:45:10Z
dc.date.available
2020-02-20T09:35:35Z
dc.date.issued
2017
dc.identifier.isbn
978-0-692-94183-6
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/237326
dc.description.abstract
We present a microfluidic tilting platform with gravity-driven flow that enables culturing of three-dimensional microtissues (MTs) under in vivo-like drug dosing regimens. In contrast to traditional, constant dosing regimens, the chip allows for gradual changes in substance concentrations. Changes in the chip operation parameters, such as the use of different tilting angles, enable to alter the drug dosage on demand. In vivo concentration curves of acetaminophen (APAP) could be approximated with the device, while feasibility experiments using preformed MTs confirmed the chip’s biocompatibility.
en_US
dc.language.iso
en
en_US
dc.publisher
Chemical and Biological Microsystems Society
en_US
dc.subject
Microfluidics
en_US
dc.subject
Tilting chip
en_US
dc.subject
Pharmacokinetics
en_US
dc.subject
3D microtissues
en_US
dc.subject
Spheroids
en_US
dc.title
A microfluidic tilting platform for in vivo-like drug exposure of three-dimensional microtissues
en_US
dc.type
Other Conference Item
ethz.book.title
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017)
en_US
ethz.pages.start
1015
en_US
ethz.pages.end
1016
en_US
ethz.event
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2017)
en_US
ethz.event.location
Savannah, GA, USA
en_US
ethz.event.date
October 22-26, 2017
en_US
ethz.notes
Poster abstract. Poster presented on October 24, 2017.
en_US
ethz.publication.place
San Diego, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02060 - Dep. Biosysteme / Dep. of Biosystems Science and Eng.::03684 - Hierlemann, Andreas / Hierlemann, Andreas
en_US
ethz.date.deposited
2018-01-30T16:10:33Z
ethz.source
FORM
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2018-01-31T06:45:13Z
ethz.rosetta.lastUpdated
2022-03-29T01:02:16Z
ethz.rosetta.versionExported
true
ethz.COinS
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