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Insights and Perspectives on Sensory-Motor Integration and Rehabilitation
(2016)Multisensory ResearchThe present review focuses on the flow and interaction of somatosensory-motor signals in the central and peripheral nervous system. Specifically, where incoming sensory signals from the periphery are processed and interpreted to initiate behaviors, and how ongoing behaviors produce sensory consequences encoded and used to fine-tune subsequent actions. We describe the structure–function relations of this loop, how these relations can be ...Journal Article -
Post-transcriptional control of executioner caspases by RNA-binding proteins
(2016)Genes & DevelopmentCaspases are key components of apoptotic pathways. Regulation of caspases occurs at several levels, including transcription, proteolytic processing, inhibition of enzymatic function, and protein degradation. In contrast, little is known about the extent of post-transcriptional control of caspases. Here, we describe four conserved RNA-binding proteins (RBPs)—PUF-8, MEX-3, GLD-1, and CGH-1—that sequentially repress the CED-3 caspase in ...Journal Article -
LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer
(2016)Genes & DevelopmentVarious tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncanonical glutamine pathway that is reliant on the mitochondrial and cytosolic transaminases glutamate pyruvate transaminase 2 (GPT2) and glutamate oxaloacetate transaminase 1 (GOT1), which ...Journal Article -
Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through sonic hedgehog
(2016)Genes & DevelopmentGrowth and regeneration of one tissue within an organ compels accommodative changes in the surrounding tissues. However, the molecular nature and operating logic governing these concurrent changes remain poorly defined. The dermal adipose layer expands concomitantly with hair follicle downgrowth, providing a paradigm for studying coordinated changes of surrounding lineages with a regenerating tissue. Here, we discover that hair follicle ...Journal Article -
Genomic imprinting in the endosperm is systematically pertubed in abortive hybrid tomato seeds
(2016)Molecular Biology and EvolutionHybrid seed failure represents an important postzygotic barrier to interbreeding among species of wild tomatoes (Solanum section Lycopersicon) and other flowering plants. We studied genome-wide changes associated with hybrid seed abortion in the closely related Solanum peruvianum and S. chilense where hybrid crosses yield high proportions of inviable seeds due to endosperm failure and arrested embryo development. Based on differences of ...Journal Article -
Conserved but Attenuated Parental Gene Expression in Allopolyploids: Constitutive Zinc Hyperaccumulation in the Allotetraploid Arabidopsis kamchatica
(2016)Molecular Biology and EvolutionAllopolyploidization combines parental genomes and often confers broader species distribution. However, little is known about parentally transmitted gene expression underlying quantitative traits following allopolyploidization because of the complexity of polyploid genomes. The allopolyploid species Arabidopsis kamchatica is a natural hybrid of the zinc hyperaccumulator Arabidopsis halleri and of the nonaccumulator Arabidopsis lyrata. We ...Journal Article -
Lagrangian analysis of sea-ice dynamics in the Arctic Ocean
(2016)Polar ResearchIn this study, we present Lagrangian diagnostics to quantify changes in the dynamical characteristics of the Arctic sea-ice cover from 2006 to 2014. Examined in particular is the evolution in finite-time Lyapunov exponents (FTLEs), which monitor the rate at which neighbouring particle trajectories diverge, and stretching rates throughout the Arctic. In this analysis, we compute FTLEs for the Arctic ice-drift field using the 62.5 km daily ...Journal Article