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The Structured Coalescent and Its Approximations
(2017)Molecular Biology and EvolutionPhylogeographic methods can help reveal the movement of genes between populations of organisms. This has been widely done to quantify pathogen movement between different host populations, the migration history of humans, and the geographic spread of languages or gene flow between species using the location or state of samples alongside sequence data. Phylogenies therefore offer insights into migration processes not available from classic ...Journal Article -
The equation of motion for supershear frictional rupture fronts
(2018)Science AdvancesThe rupture fronts that mediate the onset of frictional sliding may propagate at speeds below the Rayleigh wave speed or may surpass the shear wave speed and approach the longitudinal wave speed. While the conditions for the transition from sub-Rayleigh to supershear propagation have been studied extensively, little is known about what dictates supershear rupture speeds and how the interplay between the stresses that drive propagation and ...Journal Article -
When Evolution Works Against the Future: Disgust's Contributions to the Acceptance of New Food Technologies
(2019)Risk AnalysisNew food technologies have a high potential to transform the current resource‐consuming food system to a more efficient and sustainable one, but public acceptance of new food technologies is rather low. Such an avoidance might be maintained by a deeply preserved risk avoidance system called disgust. In an online survey, participants (N = 313) received information about a variety of new food technology applications (i.e., genetically ...Journal Article -
A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis
(2020)mAbsColorectal cancer represents the second most common cause of cancer-related death. The human A33 transmembrane glycoprotein is a validated tumor-associated antigen, expressed in 95% of primary and metastatic colorectal cancers. Using phage display technology, we generated a human monoclonal antibody (termed A2) specific to human A33 and we compared its epitope and performance to those of previously described clinical-stage anti-human A33 ...Journal Article -
PaccMann: a web service for interpretable anticancer compound sensitivity prediction
(2020)Nucleic Acids ResearchThe identification of new targeted and personalized therapies for cancer requires the fast and accurate assessment of the drug efficacy of potential compounds against a particular biomolecular sample. It has been suggested that the integration of complementary sources of information might strengthen the accuracy of a drug efficacy prediction model. Here, we present a web-based platform for the Prediction of AntiCancer Compound sensitivity ...Journal Article -
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables
(2020)Digital BiomarkersIntroduction: A major challenge in the monitoring of rehabilitation is the lack of long-term individual baseline data which would enable accurate and objective assessment of functional recovery. Consumer-grade wearable devices enable the tracking of individual everyday functioning prior to illness or other medical events which necessitate the monitoring of recovery trajectories. Methods: For 1,324 individuals who underwent surgery on a ...Journal Article -
CELLULOSE SYNTHASE INTERACTING 1 is required for wood mechanics and leaf morphology in aspen
(2020)The Plant JournalCellulose microfibrils synthesized by CELLULOSE SYNTHASE COMPLEXES (CSCs) are the main load-bearing polymers in wood. CELLULOSE SYNTHASE INTERACTING1 (CSI1) connects CSCs with cortical microtubules, which align with cellulose microfibrils. Mechanical properties of wood are dependent on cellulose microfibril alignment and structure in the cell walls, but the molecular mechanism(s) defining these features is unknown. Herein, we investigated ...Journal Article -
Numerical modeling of tectonic underplating in accretionary wedge systems
(2020)GeosphereMany fossil and active accretionary wedge systems show signs of tectonic underplating, which denotes accretion of underthrust material to the base of the wedge. Underplating is a viable process for thickening of the rear part of accretionary wedges, for example as a response to horizontal growth perpendicular to strike. Here, numerical experiments with a visco-elasto-plastic rheology are applied to test the importance of backstop geometry, ...Journal Article -
Validated Performance Prediction of Adsorption Chillers: Bridging the Gap from Gram‐Scale Experiments to Full‐Scale Chillers
(2020)Energy TechnologyAdsorption chillers provide sustainable cooling from waste or solar heat. However, adsorption chillers currently show limited performance. To increase the performance, new working pairs and adsorber geometries are constantly proposed. Evaluating the performance of new working pairs and adsorber geometries requires time and large amounts of the material. To reduce time and material needs, a method is presented to reliably predict the heat ...Journal Article -
Toward optimal metal-organic frameworks for adsorption chillers: insights from the scale-up of mil-101(cr) and nh 2 -mil-125
(2020)Energy TechnologyThe metal–organic frameworks (MOFs) MIL‐101(Cr) and NH2‐MIL‐125 offer high adsorption capacities and have therefore been suggested for sustainable energy conversion in adsorption chillers. Herein, these MOFs are benchmarked to commercial Siogel. The evaluation method combines small‐scale experiments with dynamic modeling of full‐scale adsorption chillers. For the common temperature set 10/30/80 °C, it is found that MIL‐101(Cr) has the ...Journal Article