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Bottlenecks in the provision of antenatal care: rural settled and mobile pastoralist communities in Chad
(2018)Tropical Medicine & International HealthObjective To assess antenatal care (ANC) coverage and analyse constraining factors for service delivery to rural settled and mobile populations in two districts in Chad. Method Data from cross‐sectional household and health facility surveys in the two Chadian rural health districts were analysed. First, contact coverage of ANC services in the study area was estimated from household data as the proportion of women who visited health ...Journal Article -
Are cheese-making properties of dual purpose cattle impaired by highland grazing? A case study using Aosta Red Pied cows
(2018)Italian Journal of Animal ScienceSummer transhumance is often practiced in mountainous farming systems. It includes moving dairy cows from lowland (LO) to highland (HI) pastures during summer. It is known that high genetic merit cows are susceptible to the HI conditions, but it is unclear if this also applies to more adapted, regional cow types. The present study aimed to investigate the effect of HI sojourn on cheese-making properties of Aosta Red Pied cows, a dual ...Journal Article -
Reconstruction of an informative railway wheel defect signal from wheel–rail contact signals measured by multiple wayside sensors
(2019)Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid TransitWheel impact load detectors are widespread railway systems used for measuring the wheel–rail contact force. They usually measure the rail strain and convert it to force in order to detect high impact forces and corresponding detrimental wheels. The measured strain signal can also be used to identify the defect type and its severity. The strain sensors have a limited effective zone that leads to partial observation from the wheels. Therefore, ...Journal Article -
Growth of Epithelial Organoids in a Defined Hydrogel
(2018)Advanced MaterialsEpithelial organoids are simplified models of organs grown in vitro from embryonic and adult stem cells. They are widely used to study organ development and disease, and enable drug screening in patient‐derived primary tissues. Current protocols, however, rely on animal‐ and tumor‐derived basement membrane extract (BME) as a 3D scaffold, which limits possible applications in regenerative medicine. This prompted us to study how organoids ...Journal Article -
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Programmable colloidal molecules from sequential capillarity-assisted particle assembly
(2016)Science AdvancesThe assembly of artificial nanostructured and microstructured materials which display structures and functionalities that mimic nature’s complexity requires building blocks with specific and directional interactions, analogous to those displayed at the molecular level. Despite remarkable progress in synthesizing “patchy” particles encoding anisotropic interactions, most current methods are restricted to integrating up to two compositional ...Journal Article -
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer’s disease
(2016)Science AdvancesThe conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the onset and progression of Alzheimer’s disease. Although this observation has prompted an extensive search for therapeutic agents to modulate the concentration of Aβ or inhibit its aggregation, all clinical trials with these objectives have so far failed, at least in part because of a lack of understanding of the molecular mechanisms underlying the ...Journal Article -
Domain morphology, boundaries, and topological defects in biophotonic gyroid nanostructures of butterfly wing scales
(2016)Science AdvancesMany organisms in nature have evolved sophisticated cellular mechanisms to produce photonic nanostructures and, in recent years, diverse crystalline symmetries have been identified and related to macroscopic optical properties. However, because we know little about the distributions of domain sizes, the orientations of photonic crystals, and the nature of defects in these structures, we are unable to make the connection between the ...Journal Article -
Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli
(2018)Science AdvancesWith the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest are the proteins required for the biogenesis of the asymmetric Gram-negative bacterial outer membrane (OM). Seven Lpt proteins (LptA to LptG) associate in most Gram-negative bacteria to form a macromolecular complex spanning the entire ...Journal Article