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The Evaluation of Tools Used to Predict the Impact of Missense Variants Is Hindered by Two Types of Circularity
(2015)Human MutationPrioritizing missense variants for further experimental investigation is a key challenge in current sequencing studies for exploring complex and Mendelian diseases. A large number of in silico tools have been employed for the task of pathogenicity prediction, including PolyPhen-2, SIFT, FatHMM, MutationTaster-2, MutationAssessor, Combined Annotation Dependent Depletion, LRT, phyloP, and GERP++, as well as optimized methods of combining ...Journal Article -
Pollination interactions reveal direct costs and indirect benefits of plant–plant facilitation for ecosystem engineers
(2020)Journal of Plant EcologyAims Ecosystem engineers substantially modify the environment via their impact on abiotic conditions and the biota, resulting in facilitation of associated species that would not otherwise grow. Yet, reciprocal effects are poorly understood as studies of plant–plant interactions usually estimate only benefits for associated species, while how another trophic level may mediate direct and indirect feedback effects for ecosystem engineers ...Journal Article -
De Novo Design of Bioactive Small Molecules by Artificial Intelligence
(2018)Molecular InformaticsJournal Article -
Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach
(2020)mAbsMinor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important variations concerns the N-glycosylation pattern, which directly affects an anti-tumor mechanism called antibody-dependent cell-meditated cytotoxicity (ADCC). Thus, careful engineering of mAbs is expected to enhance both protein-receptor binding and ADCC. The specific aim of this study ...Journal Article -
The size effect in corrosion greatly influences the predicted life span of concrete infrastructures
(2017)Science AdvancesForecasting the life of concrete infrastructures in corrosive environments presents a long-standing and socially relevant challenge in science and engineering. Chloride-induced corrosion of reinforcing steel in concrete is the main cause for premature degradation of concrete infrastructures worldwide. Since the middle of the past century, this challenge has been tackled by using a conceptual approach relying on a threshold chloride ...Journal Article -
Synthetic and living micropropellers for convection-enhanced nanoparticle transport
(2019)Science AdvancesNanoparticles (NPs) have emerged as an advantageous drug delivery platform for the treatment of various ailments including cancer and cardiovascular and inflammatory diseases. However, their efficacy in shuttling materials to diseased tissue is hampered by a number of physiological barriers. One hurdle is transport out of the blood vessels, compounded by difficulties in subsequent penetration into the target tissue. Here, we report the ...Journal Article